RGD Reference Report - Class II histone deacetylases: versatile regulators. - Rat Genome Database

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Class II histone deacetylases: versatile regulators.

Authors: Verdin, E  Dequiedt, F  Kasler, HG 
Citation: Verdin E, etal., Trends Genet. 2003 May;19(5):286-93.
RGD ID: 8553516
Pubmed: PMID:12711221   (View Abstract at PubMed)
DOI: DOI:10.1016/S0168-9525(03)00073-8   (Journal Full-text)

Histone acetylation and deacetylation play essential roles in modifying chromatin structure and regulating gene expression in eukaryotes. Histone deacetylases (HDACs) catalyze the deacetylation of lysine residues in the histone N-terminal tails and are found in large multiprotein complexes with transcriptional co-repressors. Human HDACs are grouped into three classes based on their similarity to known yeast factors: class I HDACs are similar to the yeast transcriptional repressor yRPD3, class II HDACs to yHDA1 and class III HDACs to ySIR2. In this review, we focus on the biology of class II HDACs. These newly discovered enzymes have been implicated as global regulators of gene expression during cell differentiation and development. We discuss their emerging biological functions and the molecular mechanisms by which they are regulated.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cytoplasm located_inTAS 8553516PMID:12711221UniProt 
histone deacetylase complex part_ofTAS 8553516PMID:12711221UniProt 
nucleus located_inTAS 8553516PMID:12711221UniProt 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
DNA-binding transcription factor binding enablesTAS 8553516PMID:12711221UniProt 
histone deacetylase activity enablesTAS 8553516PMID:12711221UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Hdac7  (histone deacetylase 7)


Additional Information