RGD Reference Report - Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones. - Rat Genome Database

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Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones.

Authors: Bennett, MK  Calakos, N  Scheller, RH 
Citation: Bennett MK, etal., Science. 1992 Jul 10;257(5067):255-9.
RGD ID: 8553325
Pubmed: PMID:1321498   (View Abstract at PubMed)

Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Two 35-kilodalton proteins (p35 or syntaxins) were identified that interact with the synaptic vesicle protein p65 (synaptotagmin). The p35 proteins are expressed only in the nervous system, are 84 percent identical, include carboxyl-terminal membrane anchors, and are concentrated on the plasma membrane at synaptic sites. An antibody to p35 immunoprecipitated solubilized N-type calcium channels. The p35 proteins may function in docking synaptic vesicles near calcium channels at presynaptic active zones.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Stx1aRatsynaptic vesicle docking involved_inIEP PMID:1321498UniProt 

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Stx1aRatmembrane located_inNAS PMID:1321498UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Stx1a  (syntaxin 1A)


Additional Information