RGD Reference Report - CART peptide diurnal rhythm in brain and effect of fasting. - Rat Genome Database

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CART peptide diurnal rhythm in brain and effect of fasting.

Authors: Vicentic, A  Lakatos, A  Hunter, R  Philpot, K  Dominguez, G  Kuhar, MJ 
Citation: Vicentic A, etal., Brain Res. 2005 Jan 25;1032(1-2):111-5.
RGD ID: 8553315
Pubmed: PMID:15680948   (View Abstract at PubMed)
DOI: DOI:10.1016/j.brainres.2004.10.053   (Journal Full-text)

We have recently shown that CART peptides exhibit a diurnal rhythm in blood that is affected by food intake and glucocorticoids. In the present study, we extend our observations by demonstrating that CART peptides also exhibit a diurnal rhythm in several brain regions, notably the nucleus accumbens, hypothalamus and amygdala, but not in the midbrain. To examine whether the CART peptide rhythm was dependent on food intake, animals were food-deprived for 24 h. In regular-fed animals, CART peptide levels were lower in the morning compared to evening hours. However, this diurnal variation of CART peptide was not apparent in fasted animals, and CART peptide levels were reduced. The diurnal variation of CART mRNA in the nucleus accumbens paralleled the variation of CART peptide in this region. Similar to the peptide, the mRNA did not change in midbrain. These results show that CART peptide levels and gene expression undergo a diurnal variation in some brain regions, and the variation is altered by fasting. These findings suggest a variety of regulatory mechanisms for CART and additional considerations for CART's role in brain.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cellular response to starvation involved_inIDA 8553315PMID:15680948HGNC-UCL 
circadian regulation of gene expression involved_inIDA 8553315PMID:15680948HGNC-UCL 

Objects Annotated

Genes (Rattus norvegicus)
Cartpt  (CART prepropeptide)


Additional Information