RGD Reference Report - Up-regulation of Toll-like receptors 2, 3 and 4 in allergic rhinitis. - Rat Genome Database

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Up-regulation of Toll-like receptors 2, 3 and 4 in allergic rhinitis.

Authors: Fransson, M  Adner, M  Erjefalt, J  Jansson, L  Uddman, R  Cardell, LO 
Citation: Fransson M, etal., Respir Res. 2005 Sep 7;6:100.
RGD ID: 8552913
Pubmed: PMID:16146574   (View Abstract at PubMed)
PMCID: PMC1243240   (View Article at PubMed Central)
DOI: DOI:10.1186/1465-9921-6-100   (Journal Full-text)

BACKGROUND: Toll-like receptors enable the host to recognize a large number of pathogen-associated molecular patterns such as bacterial lipopolysaccharide, viral RNA, CpG-containing DNA and flagellin. Toll-like receptors have also been shown to play a pivotal role in both innate and adaptive immune responses. The role of Toll-like receptors as a primary part of our microbe defense system has been shown in several studies, but their possible function as mediators in allergy and asthma remains to be established. The present study was designed to examine the expression of Toll-like receptors 2, 3 and 4 in the nasal mucosa of patients with intermittent allergic rhinitis, focusing on changes induced by exposure to pollen. METHODS: 27 healthy controls and 42 patients with seasonal allergic rhinitis volunteered for the study. Nasal biopsies were obtained before and during pollen season as well as before and after allergen challenge. The seasonal material was used for mRNA quantification of Toll-like receptors 2, 3 and 4 with real-time polymerase chain reaction, whereas specimens achieved in conjunction with allergen challenge were used for immunohistochemical localization and quantification of corresponding proteins. RESULTS: mRNA and protein representing Toll-like receptors 2, 3 and 4 could be demonstrated in all specimens. An increase in protein expression for all three receptors could be seen following allergen challenge, whereas a significant increase of mRNA only could be obtained for Toll-like receptor 3 during pollen season. CONCLUSION: The up-regulation of Toll-like receptors 2, 3 and 4 in the nasal mucosa of patients with symptomatic allergic rhinitis supports the idea of a role for Toll-like receptors in allergic airway inflammation.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TLR2Humaneye disease  IEP mRNA and protein:increased expression:nasal cavity mucosa:RGD 
TLR3Humaneye disease  IEP mRNA and protein:increased expression:nasal cavity mucosa:RGD 
TLR4Humaneye disease  IEP mRNA and protein:increased expression:nasal cavity mucosa:RGD 
Tlr2Rateye disease  ISOTLR2 (Homo sapiens)mRNA and protein:increased expression:nasal cavity mucosa:RGD 
Tlr2Mouseeye disease  ISOTLR2 (Homo sapiens)mRNA and protein:increased expression:nasal cavity mucosa:RGD 
Tlr3Rateye disease  ISOTLR3 (Homo sapiens)mRNA and protein:increased expression:nasal cavity mucosa:RGD 
Tlr3Mouseeye disease  ISOTLR3 (Homo sapiens)mRNA and protein:increased expression:nasal cavity mucosa:RGD 
Tlr4Rateye disease  ISOTLR4 (Homo sapiens)mRNA and protein:increased expression:nasal cavity mucosa:RGD 
Tlr4Mouseeye disease  ISOTLR4 (Homo sapiens)mRNA and protein:increased expression:nasal cavity mucosa:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tlr2  (toll-like receptor 2)
Tlr3  (toll-like receptor 3)
Tlr4  (toll-like receptor 4)

Genes (Mus musculus)
Tlr2  (toll-like receptor 2)
Tlr3  (toll-like receptor 3)
Tlr4  (toll-like receptor 4)

Genes (Homo sapiens)
TLR2  (toll like receptor 2)
TLR3  (toll like receptor 3)
TLR4  (toll like receptor 4)


Additional Information