RGD Reference Report - CCR5 and CCR3 expression on T CD3+ lymphocytes from HIV/Leishmania co-infected subjects. - Rat Genome Database

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CCR5 and CCR3 expression on T CD3+ lymphocytes from HIV/Leishmania co-infected subjects.

Authors: Nigro, L  Rizzo, ML  Vancheri, C  La Rosa, R  Mastruzzo, C  Tomaselli, V  Ragusa, A  Manuele, R  Cacopardo, B 
Citation: Nigro L, etal., Med Microbiol Immunol. 2007 Dec;196(4):253-5. Epub 2007 Apr 25.
RGD ID: 8551841
Pubmed: PMID:17457607   (View Abstract at PubMed)
DOI: DOI:10.1007/s00430-007-0046-1   (Journal Full-text)

CC chemokine receptor 5 (CCR5) and CC chemokine receptor 3 (CCR3) are membrane-bound proteins involved in HIV-1 entry into susceptible cells. All T lymphocyte subsets display CCR5 and CCR3 on their membrane surface. T helper 1 cells are known to express CCR5 but not CCR3, and most of T cells expressing CCR3 are T helper 2. This study aimed to assess the expression of CCR5 and CCR3 on peripheral blood CD3+ T lymphocytes of HIV-Leishmania co-infected individuals. A total of 36 subjects were enrolled; nine had HIV-Leishmania co-infection; nine were HIV-infected without Leishmania, nine had visceral leishmaniasis without HIV co-infection and nine were healthy blood donors. HIV-Leishmania co-infected subjects showed a significantly higher rate of CCR5+CD3+ T lymphocytes in comparison with the other studied groups. The higher rate of CD3+ T-cells expressing CCR5 found in HIV-Leishmania co-infected subjects may be related to the role of Leishmania as an enhancer of the progression to AIDS.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CCR5Humanleishmaniasis  IEP associated with HIV Infections more ...RGD 
Ccr5Ratleishmaniasis  ISOCCR5 (Homo sapiens)associated with HIV Infections more ...RGD 
Ccr5Mouseleishmaniasis  ISOCCR5 (Homo sapiens)associated with HIV Infections more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccr5  (C-C motif chemokine receptor 5)

Genes (Mus musculus)
Ccr5  (C-C motif chemokine receptor 5)

Genes (Homo sapiens)
CCR5  (C-C motif chemokine receptor 5)


Additional Information