RGD Reference Report - CD40 is required for development of islet inflammation in the RIP-CD154 transgenic mouse model of type 1 diabetes. - Rat Genome Database

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CD40 is required for development of islet inflammation in the RIP-CD154 transgenic mouse model of type 1 diabetes.

Authors: Haase, C  Markholst, H 
Citation: Haase C and Markholst H, Ann N Y Acad Sci. 2007 Jun;1107:373-9.
RGD ID: 8547791
Pubmed: PMID:17804565   (View Abstract at PubMed)
DOI: DOI:10.1196/annals.1381.039   (Journal Full-text)

Type 1 diabetes is believed to be an autoimmune disease where cells of the immune system destroy the insulin-producing beta cells in the islets of Langerhans. The trigger(s) of the inflammatory reaction is yet unknown, but both genetic and environmental factors, including viruses or other pathogens, are thought to play a role. We have recently described a transgenic mouse model--the RIP-CD154 mouse--in which beta-cell-specific expression of CD154 (CD40 ligand) mediates immune activation, insulitis, and diabetes on a non-diabetes-prone background. By the use of bone marrow chimeric mice, we now demonstrate that a functional Cd40 gene is necessary for islet inflammation and we show that CD40 expression on bone marrow-derived cells is sufficient to trigger activation of the immune system and development of insulitis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Inflammation  ISOCd40 (Mus musculus)8547791; 8547791associated with Diabetes Mellitus and Type 1RGD 
Inflammation  IMP 8547791associated with Diabetes Mellitus and Type 1RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cd40  (CD40 molecule)

Genes (Mus musculus)
Cd40  (CD40 antigen)

Genes (Homo sapiens)
CD40  (CD40 molecule)


Additional Information