RGD Reference Report - Genetic response to an environmental pathogenic agent: HLA-DQ and onchocerciasis in northwestern Ecuador. - Rat Genome Database

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Genetic response to an environmental pathogenic agent: HLA-DQ and onchocerciasis in northwestern Ecuador.

Authors: De Angelis, F  Garzoli, A  Battistini, A  Iorio, A  De Stefano, GF 
Citation: De Angelis F, etal., Tissue Antigens. 2012 Feb;79(2):123-9. doi: 10.1111/j.1399-0039.2011.01811.x. Epub 2011 Nov 26.
RGD ID: 8547660
Pubmed: PMID:22117902   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1399-0039.2011.01811.x   (Journal Full-text)

The aim of this study is to explore human leukocyte antigen (HLA)-DQ variability in two populations (Cayapas Amerindians and Afro-Ecuadorians) who live near one another along the Cayapa River and who are exposed to the same environmental stresses, such as infection by Onchocerca volvulus. HLA-DQA1 and HLA-DQB1 of 149 unrelated individuals (74 Cayapas and 75 Afro-Ecuadorians) have been analyzed. HLA high-resolution molecular typing was performed by sequence-based typing, sequence-specific oligonucleotides hybridization and sequence-specific primer (SSP) amplification. The comparison between affected (cases) and unaffected people (controls) in both populations shows the key role of several HLA-DQA1 alleles in susceptibility and protection against onchocerciasis. In both populations, there is strong evidence related to the protective role of DQA1*0401 against onchocerciasis. Alleles HLA-DQA1*0102 and *0103 seem to represent risk factors in Afro-Ecuadorians, while HLA-DQA1*0301 is only a suggestive susceptibility allele in Cayapas. These findings represent new positive/negative associations with onchocerciasis in South America, whereas previous findings pertained only to African populations.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
H2-AaMouseonchocerciasis susceptibilityISOHLA-DQA1 (Homo sapiens)DNA:polymorphisms: :HLA-DQA1*0401 more ...RGD 
HLA-DQA1Humanonchocerciasis susceptibilityIAGP DNA:polymorphisms: :HLA-DQA1*0401 more ...RGD 
RT1-BaRatonchocerciasis susceptibilityISOHLA-DQA1 (Homo sapiens)DNA:polymorphisms: :HLA-DQA1*0401 more ...RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HLA-DQA1HumanSkin nodule susceptibilityIAGP DNA:polymorphisms: :HLA-DQA1*0401 more ...RGD 
HLA-DQA1HumanUnusual parasitic infection susceptibilityIAGP DNA:polymorphisms: :HLA-DQA1*0401 more ...RGD 
Objects Annotated

Genes (Rattus norvegicus)
RT1-Ba  (RT1 class II, locus Ba)

Genes (Mus musculus)
H2-Aa  (histocompatibility 2, class II antigen A, alpha)

Genes (Homo sapiens)
HLA-DQA1  (major histocompatibility complex, class II, DQ alpha 1)


Additional Information