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Pattern of tau isoforms expression during development in vivo.

Authors: Bullmann, T  Holzer, M  Mori, H  Arendt, T 
Citation: Bullmann T, etal., Int J Dev Neurosci. 2009 Oct;27(6):591-7. doi: 10.1016/j.ijdevneu.2009.06.001. Epub 2009 Jun 18.
Pubmed: (View Article at PubMed) PMID:19540327
DOI: Full-text: DOI:10.1016/j.ijdevneu.2009.06.001

Neuronal morphology and axonal growth during development are correlated to specific expression of various microtubule-associated protein tau isoforms. Using RT-PCR and Western blotting we found the unexpected result that the shift from fetal towards adult isoforms does not differ between rat cerebral cortex and cerebellum, two temporally differently developing areas. By immunohistochemistry we observed a cell type specific isoform expression during development and adulthood. The developmental expression of tau isoforms was compared to the appearance of stable microtubules assessed by the immunohistochemical detection of tubulin modifications. The tau isoform shift shows an apparent disconnect to neurogenesis, migration and volume growth, but coincides with the formation of synapses and the appearance of stable microtubules.


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RGD Object Information
RGD ID: 8158109
Created: 2014-02-10
Species: All species
Last Modified: 2014-02-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.