RGD Reference Report - In vivo effects of interferon-gamma and anti-interferon-gamma antibody on the experimentally induced lichenoid tissue reaction. - Rat Genome Database

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In vivo effects of interferon-gamma and anti-interferon-gamma antibody on the experimentally induced lichenoid tissue reaction.

Authors: Shiohara, T  Nickoloff, BJ  Moriya, N  Gotoh, C  Nagashima, M 
Citation: Shiohara T, etal., Br J Dermatol. 1988 Aug;119(2):199-206.
RGD ID: 8157617
Pubmed: PMID:3139020   (View Abstract at PubMed)

We investigated the in vivo effect of recombinant interferon-gamma (IFN-gamma) and tumour necrosis factor alpha (TNF-alpha) treatment of mice on the development of the delayed-type hypersensitivity (DTH) reaction and lichenoid tissue reaction (LTR) following the local injection of cloned autoreactive T cells. Both the DTH reaction and the LTR were significantly enhanced by pretreatment with IFN-gamma, but not with TNF-alpha. Induction of class II MHC antigens on keratinocytes was not essential for the enhancement by IFN-gamma. Administration of anti-IFN-gamma antibody reduced the DTH reaction and LTR, although complete inhibition was not observed with our treatment regimen. The ability of IFN-gamma to increase the number of the cloned T cells invading the epidermis in vivo, is in keeping with our previous observation that IFN-gamma treatment of cultured keratinocytes markedly increased the adherence reaction between T cells and keratinocytes in vitro.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Objects Annotated

Genes (Rattus norvegicus)
Ifng  (interferon gamma)

Genes (Mus musculus)
Ifng  (interferon gamma)

Genes (Homo sapiens)
IFNG  (interferon gamma)


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