RGD Reference Report - Identification of QTLs involved in the development of amygdala kindling in the rat. - Rat Genome Database

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Identification of QTLs involved in the development of amygdala kindling in the rat.

Authors: Hashimoto, R  Voigt, B  Ishimaru, Y  Hokao, R  Chiba, S  Serikawa, T  Sasa, M  Kuramoto, T 
Citation: Hashimoto R, etal., Exp Anim. 2013;62(3):181-7.
RGD ID: 7794751
Pubmed: PMID:23903052   (View Abstract at PubMed)
PMCID: PMC4160946   (View Article at PubMed Central)

Amygdala kindling is useful for modeling human epilepsy development. It has been known that genetic factors are involved in the development of amygdala kindling. The purpose of this study was to identify the loci that are responsible for the development of amygdala kindling. To achieve this, rat strains from a LEXF/FXLE recombinant inbred (RI) strain panel were used. The phenotypes of amygdala kindling-related parameters for seven RI strains and parental LE/Stm and F344/Stm strains were determined. They included the afterdischarge threshold (ADT), the afterdischarge duration (ADD), and the kindling rate, an incidence of development of kindling. Quantitative trait loci (QTL) analysis was performed to identify linkage relationships between these phenotypes and 1,033 SNP markers. Although no significant differences in pre-kindling ADT and ADD were observed, a significant difference in the kindling rate was found for the LEXF/FXLE RI strain. Two QTLs for the amygdala kindling rate (Agkr1 and Agkr2) were identified on rat chromosome 2. These findings clearly prove the existence of genetic influences that are involved in kindling development and suggest that substantial genetic components contribute to the progression of partial seizures into generalized seizures.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Swd6Ratepilepsy  IAGP  RGD 
Swd7Ratepilepsy  IAGP  RGD 
Swd6Ratneurodegenerative disease  IAGP  RGD 
Swd7Ratneurodegenerative disease  IAGP  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Swd6Ratabnormal kindling response  IDA  RGD 
Swd7Ratabnormal kindling response  IDA  RGD 
Objects Annotated

QTLs
Swd6  (Spike wave discharge measurement QTL 6)
Swd7  (Spike wave discharge measurement QTL 7)

Strains
LEXF10C/Stm  (NA)

Objects referenced in this article
Marker rs65697820 rs65697820 Rattus norvegicus
Marker rs105751187 rs105751187 Rattus norvegicus
Marker rs105606024 rs105606024 Rattus norvegicus
Marker rs105301743 rs105301743 Rattus norvegicus
Marker rs106578723 rs106578723 Rattus norvegicus
Marker rs105660993 rs105660993 Rattus norvegicus
Strain F344/Stm null Rattus norvegicus
Strain FXLE13/Stm null Rattus norvegicus
Strain FXLE16/Stm null Rattus norvegicus
Strain LE/Stm null Rattus norvegicus
Strain LEXF11/Stm null Rattus norvegicus
Strain LEXF2B/Stm null Rattus norvegicus
Strain LEXF6B/Stm null Rattus norvegicus
Strain LEXF7B/Stm null Rattus norvegicus

Additional Information