RGD Reference Report - Differential regulation of Toll-like receptor mRNAs in experimental murine central nervous system infections. - Rat Genome Database

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Differential regulation of Toll-like receptor mRNAs in experimental murine central nervous system infections.

Authors: Bottcher, T  Von Mering, M  Ebert, S  Meyding-Lamade, U  Kuhnt, U  Gerber, J  Nau, R 
Citation: Bottcher T, etal., Neurosci Lett. 2003 Jun 19;344(1):17-20.
RGD ID: 7794740
Pubmed: (View Article at PubMed) PMID:12781911

Toll-like receptors (TLR) play a key role in the recognition of microbial components. We investigated the differential regulation of TLR mRNA expression in bacterial and viral mouse models of central nervous system infection. Streptococcus pneumoniae meningitis led to an enhanced expression of TLR2, TLR4 and TLR9 mRNA. In Escherichia coli meningitis, TLR2, TLR4 and TLR7 mRNA expression was increased and Herpes simplex encephalitis caused a rise of TLR4 mRNA. In organotypic hippocampal cultures treatment with S. pneumoniae R6 led to increased expression of TLR2 and TLR3 mRNA. Our data provide evidence that regulation of TLR mRNA is not fully specific for the molecular patterns of the infectious pathogen. The TLR mRNA regulation observed probably represents a combination of specific response to the causative pathogen and non-specific activation of the innate immune system.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Tlr2  (toll-like receptor 2)
Tlr4  (toll-like receptor 4)
Tlr7  (toll-like receptor 7)
Tlr9  (toll-like receptor 9)

Genes (Mus musculus)
Tlr2  (toll-like receptor 2)
Tlr4  (toll-like receptor 4)
Tlr7  (toll-like receptor 7)
Tlr9  (toll-like receptor 9)

Genes (Homo sapiens)
TLR2  (toll like receptor 2)
TLR4  (toll like receptor 4)
TLR7  (toll like receptor 7)
TLR9  (toll like receptor 9)


Additional Information