RGD Reference Report - Rapid communication. Enalapril decreases nuclear factor kappa B activation in the kidney with ureteral obstruction. - Rat Genome Database

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Rapid communication. Enalapril decreases nuclear factor kappa B activation in the kidney with ureteral obstruction.

Authors: Morrissey, JJ  Klahr, S 
Citation: Morrissey JJ and Klahr S, Kidney Int. 1997 Oct;52(4):926-33.
RGD ID: 7777163
Pubmed: PMID:9328931   (View Abstract at PubMed)

The transcription factor nuclear factor kappa B (NF-kappa B) controls a number of genes associated with tissue inflammation and has been shown to be activated in the kidney with ureteral obstruction. In this investigation, we further explored NF-kappa B activation in the kidney cortex of rats with unilateral ureteral obstruction. Electrophoretic mobility shift assays combined with antibody supershift/depletion demonstrated that NF-kappa B subunits p50, p52, c-rel, p65 (RelA) and RelB were all activated. Immunocytochemical analysis using an antibody to the p50 subunit demonstrated activation occurring predominantly in nuclei of tubular cells. Treatment of animals with unilateral ureteral obstruction with an oral ACE inhibitor significantly decreased NF-kappa B activation. This suggests that the antiinflammatory effect of ACE inhibitors in renal disease is in part due to a blunting of NF-kappa B activation.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
ureteral obstruction  ISORelb (Rattus norvegicus)7777163; 7777163protein:increased activity:kidneyRGD 
ureteral obstruction  IDA 7777163protein:increased activity:kidneyRGD 

Objects Annotated

Genes (Rattus norvegicus)
Relb  (RELB proto-oncogene, NF-kB subunit)

Genes (Mus musculus)
Relb  (avian reticuloendotheliosis viral (v-rel) oncogene related B)

Genes (Homo sapiens)
RELB  (RELB proto-oncogene, NF-kB subunit)


Additional Information