RGD Reference Report - Rel B is an early marker of autoimmune islet inflammation in the biobreeding (BB) rat. - Rat Genome Database

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Rel B is an early marker of autoimmune islet inflammation in the biobreeding (BB) rat.

Authors: Bieg, S  Simonson, W  Ellefsen, K  Lernmark, A 
Citation: Bieg S, etal., Pancreas. 2000 Jan;20(1):47-54.
RGD ID: 7777162
Pubmed: PMID:10630383   (View Abstract at PubMed)

Because the development of insulitis and diabetes is predictable in Lyp/Lyp congenic BB rats, we have characterized early islet inflammation in these rats to determine the cell subsets involved in the onset of autoimmune insulitis. Pancreas sections from prediabetic Lyp/Lyp, Lyp/+ and +/+ rats were analyzed by immunohistochemistry. We found W3/25+ cells in the exo- and endocrine tissue from all three genotypes, but intraislet insulitis was never found in Lyp/+ or +/+ rats. The onset of massive, intraislet B- and T-cell infiltration in Lyp/Lyp rats was preceded by Rel B+ cells in and around the islets, followed by ED1+ monocytes/macrophages. Rel B+ cells were more frequent in the parafollicular cortex of pancreatic lymph nodes from Lyp/Lyp than from Lyp/+ and +/+ rats. In the Lyp/Lyp thymus, we found significantly increased expression of IL-12p40 messenger RNA (mRNA; p<0.001), located in the Rel B-protein-rich corticomedullary junction. The NF-KB/Rel B complex specifically transactivates genes involved in antigen presentation in dendritic cells. Rel B+ cells in the islets may therefore mark the onset of autoimmune insulitis and antigen-specific activation of autoreactive T cells in the lymph nodes of diabetes prone Lyp/Lyp BB rats. In the thymus, Rel B+ cells may support the Lyp-dependent development of self-reactive thymocytes by activation of cytokine expression.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
prediabetes syndrome  ISORelb (Rattus norvegicus)7777162; 7777162protein:increased expression:pancreatic islet RGD 
prediabetes syndrome  IEP 7777162protein:increased expression:pancreatic islet RGD 

Objects Annotated

Genes (Rattus norvegicus)
Relb  (RELB proto-oncogene, NF-kB subunit)

Genes (Mus musculus)
Relb  (avian reticuloendotheliosis viral (v-rel) oncogene related B)

Genes (Homo sapiens)
RELB  (RELB proto-oncogene, NF-kB subunit)


Additional Information