RGD Reference Report - Lack of evidence for association between endothelial nitric oxide synthase gene polymorphism (glu298asp) with Behcet's disease in the Turkish population. - Rat Genome Database

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Lack of evidence for association between endothelial nitric oxide synthase gene polymorphism (glu298asp) with Behcet's disease in the Turkish population.

Authors: Kara, N  Senturk, N  Gunes, SO  Bagci, H  Yigit, S  Turanli, AY 
Citation: Kara N, etal., Arch Dermatol Res. 2006 Apr;297(10):468-71. Epub 2006 Feb 7.
RGD ID: 7771577
Pubmed: (View Article at PubMed) PMID:16463158
DOI: Full-text: DOI:10.1007/s00403-006-0643-7

Endothelial nitric oxide synthase (eNOS) could be a candidate gene for Behcet's disease (BD). This study investigated the relationship of the eNOS Glu298 --> Asp polymorphism with the presence and severity of BD in the Turkish population. Ninety-two patients with BD and 100 controls were studied. Analyses of Glu298Asp polymorphism in exon 7 of the eNOS gene were made by the polymerase chain reaction (PCR)-restriction fragment length polymorphism technique. The frequencies of the eNOS genotypes were similar for BD patients (GG:GT:TT = 58.7%:38%:3.3%) and controls (59.2%:33.7%:7.1 %), P = 0.335. No evidence of difference was found in the frequency of the T allele between BD patients (22.3%) and controls (24%), [OR = 0.91, 95% CI (0.55-1.50), P = 0.690]. Glu298 --> Asp polymorphism of the eNOS gene does not appear to be associated with the presence of BD in the Turkish population.

Annotation

Disease Annotations    
Behcet's disease  (IAGP,ISO)

Phenotype Annotations    

Human Phenotype
Genital ulcers  (IAGP)
Oral ulcer  (IAGP)
Uveitis  (IAGP)
Objects Annotated

Genes (Rattus norvegicus)
Nos3  (nitric oxide synthase 3)

Genes (Mus musculus)
Nos3  (nitric oxide synthase 3, endothelial cell)

Genes (Homo sapiens)
NOS3  (nitric oxide synthase 3)


Additional Information