RGD Reference Report - Polymorphisms in genes involved in the free-radical process in patients with sudden sensorineural hearing loss and Meniere's disease. - Rat Genome Database

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Polymorphisms in genes involved in the free-radical process in patients with sudden sensorineural hearing loss and Meniere's disease.

Authors: Teranishi, M  Uchida, Y  Nishio, N  Kato, K  Otake, H  Yoshida, T  Suzuki, H  Sone, M  Sugiura, S  Ando, F  Shimokata, H  Nakashima, T 
Citation: Teranishi M, etal., Free Radic Res. 2013 Jul;47(6-7):498-506. doi: 10.3109/10715762.2013.793319. Epub 2013 May 7.
RGD ID: 7771541
Pubmed: (View Article at PubMed) PMID:23560644
DOI: Full-text: DOI:10.3109/10715762.2013.793319

The etiologies of idiopathic sudden sensorineural hearing loss (SSNHL) and Meniere's disease remain unclear. Recently, accumulating evidence has demonstrated that free radicals are related to the pathology of inner ear disease. Because genetic factors may contribute partly to the etiologies of SSNHL and Meniere's disease, we investigated the association between genetic polymorphisms located in genes related to the free-radical process and susceptibility to SSNHL and Meniere's disease. We compared 83 patients affected by SSNHL and 83 patients affected by Meniere's disease with 2048 adults (for SSNHL) and 1946 adults (for Meniere's disease) who participated in the National Institute for Longevity Sciences, Longitudinal Study of Aging. Multiple logistic regression was used to calculate odds ratios (ORs) for SSNHL and Meniere's disease in individuals with polymorphisms in the genes: methionine synthase (MTR; rs1805087); methionine-synthase reductase (MTRR; rs1801394); nitric oxide synthase 3 (NOS3; rs1799983); caveolin 1 (Cav1; rs3840634); melatonin receptor 1B (MTNR1B; rs1387153); NAD(P)H oxidase p22(phox) subunit (NADH/NADPHp22phox; rs4673); and mitochondria 5178 (MT5178; rs28357984). The NOS3 polymorphism was significantly associated with a risk of SSNHL; in addition, the OR for the NOS3 polymorphism and SSNHL risk was 2.108 (CI, 1.343-3.309) with adjustment for age and sex. The Cav1 polymorphism was significantly associated with a risk of Meniere's disease; moreover, the OR for the Cav1 polymorphism and Meniere's disease risk was 1.849 (CI, 1.033-3.310) with adjustment for age and sex. In conclusion, the NOS3 and Cav1 polymorphisms were significantly associated with the risk of SSNHL and Meniere's disease, respectively.

Annotation

Disease Annotations    
Sudden Hearing Loss  (IAGP,ISO)

Objects Annotated

Genes (Rattus norvegicus)
Nos3  (nitric oxide synthase 3)

Genes (Mus musculus)
Nos3  (nitric oxide synthase 3, endothelial cell)

Genes (Homo sapiens)
NOS3  (nitric oxide synthase 3)


Additional Information