RGD Reference Report - Junctional adhesion molecule-1 is upregulated in spontaneously hypertensive rats: evidence for a prohypertensive role within the brain stem. - Rat Genome Database

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Junctional adhesion molecule-1 is upregulated in spontaneously hypertensive rats: evidence for a prohypertensive role within the brain stem.

Authors: Waki, H  Liu, B  Miyake, M  Katahira, K  Murphy, D  Kasparov, S  Paton, JF 
Citation: Waki H, etal., Hypertension. 2007 Jun;49(6):1321-7. Epub 2007 Apr 9.
RGD ID: 7488939
Pubmed: PMID:17420334   (View Abstract at PubMed)
DOI: DOI:10.1161/HYPERTENSIONAHA.106.085589   (Journal Full-text)

Junctional adhesion molecule-1 (JAM-1) forms part of the tight junction between adjacent endothelial cells. Using microarray technology, we showed previously that JAM-1 was differentially expressed in the brain stem of spontaneously hypertensive rats compared with normotensive Wistar-Kyoto (WKY) rats. In this study, we quantified the expression of JAM-1 in the brain stem of spontaneously hypertensive rats and WKY rats and established whether any differential expression was confined to this region of the brain or was ubiquitous throughout the central nervous system and, indeed, the whole body. Because the nucleus tractus solitarii plays a pivotal role in arterial pressure regulation, we assessed whether JAM-1 in this region affects the chronic regulation of arterial pressure. Real time RT-PCR revealed that JAM-1 mRNA was upregulated in multiple regions of the brain and all of the peripheral vascular beds studied. In the nucleus tractus solitarii, the level of JAM-1 mRNA was significantly higher in both young (3-week-old, prehypertensive) and adult male spontaneously hypertensive rats (15 to 18 weeks old) than that of age-matched WKY rats (fold differences; prehypertensives: 1.01+/-0.06 versus 1.59+/-0.13; n=10; P<0.01; adult: 1.08+/-0.14 versus 2.86+/-0.57; n=10; P<0.01). After adenoviral-mediated expression of JAM-1 in the nucleus tractus solitarii of adult WKY rats (15 weeks old; n=6), systolic pressure was increased from 120+/-4 to 132+/-4 mm Hg (P<0.01). Our data suggest that JAM-1 expression in the spontaneously hypertensive rat is upregulated throughout the body compared with the WKY rat and that this is not secondary to the hypertension. When JAM-1 is expressed in the nucleus tractus solitarii, it raises arterial pressure, suggesting a novel prohypertensive role for this protein within the brain stem.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hypertension  ISOF11r (Rattus norvegicus)7488939; 7488939 RGD 
hypertension  IEP 7488939 RGD 
Prehypertension  ISOF11r (Rattus norvegicus)7488939; 7488939 RGD 
Prehypertension  IEP 7488939 RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
positive regulation of blood pressure  IDA 7488939 RGD 

Objects Annotated

Genes (Rattus norvegicus)
F11r  (F11 receptor)

Genes (Mus musculus)
F11r  (F11 receptor)

Genes (Homo sapiens)
F11R  (F11 receptor)


Additional Information