RGD Reference Report - Increased expression of vascular permeability factor (vascular endothelial growth factor) in bullous pemphigoid, dermatitis herpetiformis, and erythema multiforme. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Increased expression of vascular permeability factor (vascular endothelial growth factor) in bullous pemphigoid, dermatitis herpetiformis, and erythema multiforme.

Authors: Brown, LF  Harrist, TJ  Yeo, KT  Stahle-Backdahl, M  Jackman, RW  Berse, B  Tognazzi, K  Dvorak, HF  Detmar, M 
Citation: Brown LF, etal., J Invest Dermatol. 1995 May;104(5):744-9.
RGD ID: 7421578
Pubmed: PMID:7738351   (View Abstract at PubMed)

Vascular permeability factor (VPF), also known as vascular endothelial growth factor (VEGF), plays an important role in the increased vascular permeability and angiogenesis associated with many malignant tumors. In addition, VPF/VEGF is strongly expressed by epidermal keratinocytes in wound healing and psoriasis, disorders that are also characterized by increased microvascular permeability and angiogenesis. In this study, we investigated the expression of VPF/VEGF in three bullous diseases with subepidermal blister formation that are characterized by hyperpermeable dermal microvessels and pronounced papillary dermal edema. The expression of VPF/VEGF mRNA was strongly up-regulated in the lesional epidermis of bullous pemphigoid (n = 3), erythema multiforme (n = 3), and dermatitis herpetiformis (n = 4) as detected by in situ hybridization. Epidermal labeling was particularly intense over blisters, but strong expression was also noted in areas of the epidermis adjacent to dermal inflammatory infiltrates at a distance from blisters. Moreover, the VPF/VEGF receptors, flt-1 and KDR, were up-regulated in endothelial cells in superficial dermal microvessels. High levels of VPF/VEGF (138-238 pM) were detected in blister fluids obtained from five patients with bullous pemphigoid. Addition of blister fluid to human dermal microvascular endothelial cells exerted a dose-dependent mitogenic effect that was suppressed after depletion of VPF/VEGF by immunoadsorption. These findings strongly suggest that VPF/VEGF plays an important role in the induction of increased microvascular permeability in bullous diseases, leading to papillary edema and fibrin deposition and contributing to the bulla formation characteristic of these disorders.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
VEGFAHumanbullous pemphigoid  IEP mRNA:increased expression: :RGD 
VegfaRatbullous pemphigoid  ISOVEGFA (Homo sapiens)mRNA:increased expression: :RGD 
VegfaMousebullous pemphigoid  ISOVEGFA (Homo sapiens)mRNA:increased expression: :RGD 
VEGFAHumandermatitis herpetiformis  IEP mRNA:increased expression: :RGD 
VegfaRatdermatitis herpetiformis  ISOVEGFA (Homo sapiens)mRNA:increased expression: :RGD 
VegfaMousedermatitis herpetiformis  ISOVEGFA (Homo sapiens)mRNA:increased expression: :RGD 
VEGFAHumanerythema multiforme  IEP mRNA:increased expression: :RGD 
VegfaRaterythema multiforme  ISOVEGFA (Homo sapiens)mRNA:increased expression: :RGD 
VegfaMouseerythema multiforme  ISOVEGFA (Homo sapiens)mRNA:increased expression: :RGD 

Objects Annotated

Genes (Rattus norvegicus)
Vegfa  (vascular endothelial growth factor A)

Genes (Mus musculus)
Vegfa  (vascular endothelial growth factor A)

Genes (Homo sapiens)
VEGFA  (vascular endothelial growth factor A)


Additional Information