RGD Reference Report - Carboxypeptidase M augments kinin B1 receptor signaling by conformational crosstalk and enhances endothelial nitric oxide output. - Rat Genome Database

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Carboxypeptidase M augments kinin B1 receptor signaling by conformational crosstalk and enhances endothelial nitric oxide output.

Authors: Zhang, X  Tan, F  Brovkovych, V  Zhang, Y  Lowry, JL  Skidgel, RA 
Citation: Zhang X, etal., Biol Chem. 2013 Mar;394(3):335-45. doi: 10.1515/hsz-2012-0290.
RGD ID: 7411632
Pubmed: PMID:23183746   (View Abstract at PubMed)
PMCID: PMC3566571   (View Article at PubMed Central)
DOI: DOI:10.1515/hsz-2012-0290   (Journal Full-text)

The G protein-coupled receptors (GPCRs) are the largest class of membrane proteins that play key roles in transducing extracellular signals to intracellular proteins to generate cellular responses. The kinin GPCRs, named B1 (B1R) and B2 (B2R), are responsible for mediating the biological responses to kinin peptides released from the precursor kininogens. Bradykinin (BK) or kallidin (KD) are agonists for B2Rs, whereas their carboxypeptidase (CP)-generated metabolites, des-Arg(9)-BK or des-Arg(10)-KD, are specific agonists for B1Rs. Here, we review the evidence for a critical role of membrane-bound CPM in facilitating B1R signaling by its ability to directly activate the receptor via conformational crosstalk as well as generate its specific agonist. In endothelial cells, the CPM/B1R interaction facilitates B1R-dependent high-output nitric oxide under inflammatory conditions.


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