RGD Reference Report - QTLs influencing carbohydrate and fat choice in a LOU/CxFischer 344 F2 rat population. - Rat Genome Database

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QTLs influencing carbohydrate and fat choice in a LOU/CxFischer 344 F2 rat population.

Authors: Marissal-Arvy, N  Diane, A  Moisan, MP  Larue-Achagiotis, C  Tridon, C  Tome, D  Fromentin, G  Mormede, P 
Citation: Marissal-Arvy N, etal., Obesity (Silver Spring). 2013 Apr 17. doi: 10.1002/oby.20485.
RGD ID: 7401255
Pubmed: PMID:23596094   (View Abstract at PubMed)
DOI: DOI:10.1002/oby.20485   (Journal Full-text)

OBJECTIVE: Individual differences in macronutrient selection, particularly fat and carbohydrate, and associated body weight gain are partly inherited as polygenic traits, but the potential genetic pathways are unknown. To give an overview of the Quantitative Trait Loci (QTLs) and candidate gene pathways influencing these differences in rat was aimed in this study. DESIGN AND METHODS: To that end, F2 rats obtained from the crossbreeding between LOU/C and Fischer 344 rat strains to diet self-selection during 3 weeks were submitted. A genome scan was conducted with microsatellite markers covering evenly the whole genome. Genotypes and phenotypes were analyzed separately in male and female F2 rats by multiple interval mapping. Then, lists of candidate genes were treated by the Ingenuity(R) Pathway software to propose gene pathways involved in our phenotypes. RESULTS: Among numerous others, a QTL on chromosome 12 that influences body weight gain, and fat and carbohydrate choices in the LOU/C x Fischer 344 F2 rat population was found. This locus contains notably the acyl-co-A dehydrogenase gene. CONCLUSION: A strong genetic determinism and complex pathways involving numerous candidate genes and processes, notably in accordance with the metabolic theory of feeding behavior control were found.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bw127RatBody Weight  IAGP  RGD 
Bw128RatBody Weight  IAGP  RGD 
Bw129RatBody Weight  IAGP  RGD 
Bw130RatBody Weight  IAGP  RGD 
Bw131RatBody Weight  IAGP  RGD 
Bw132RatBody Weight  IAGP  RGD 
Bw133RatBody Weight  IAGP  RGD 
Bw134RatBody Weight  IAGP  RGD 
Bw135RatBody Weight  IAGP  RGD 
Bw136RatBody Weight  IAGP  RGD 
Bw137RatBody Weight  IAGP  RGD 
Bw138RatBody Weight  IAGP  RGD 
Bw139RatBody Weight  IAGP  RGD 
Bw140RatBody Weight  IAGP  RGD 
Bw141RatBody Weight  IAGP  RGD 
Bw142RatBody Weight  IAGP  RGD 
Foco10RatBody Weight  IAGP  RGD 
Foco11RatBody Weight  IAGP  RGD 
Foco12RatBody Weight  IAGP  RGD 
Foco13RatBody Weight  IAGP  RGD 
Foco14RatBody Weight  IAGP  RGD 
Foco15RatBody Weight  IAGP  RGD 
Foco16RatBody Weight  IAGP  RGD 
Foco17RatBody Weight  IAGP  RGD 
Foco18RatBody Weight  IAGP  RGD 
Foco19RatBody Weight  IAGP  RGD 
Foco20RatBody Weight  IAGP  RGD 
Foco21RatBody Weight  IAGP  RGD 
Foco22RatBody Weight  IAGP  RGD 
Foco23RatBody Weight  IAGP  RGD 
Foco24RatBody Weight  IAGP  RGD 
Foco25RatBody Weight  IAGP  RGD 
Foco26RatBody Weight  IAGP  RGD 
Foco27RatBody Weight  IAGP  RGD 
Foco28RatBody Weight  IAGP  RGD 
Foco29RatBody Weight  IAGP  RGD 
Foco3RatBody Weight  IAGP  RGD 
Foco30RatBody Weight  IAGP  RGD 
Foco31RatBody Weight  IAGP  RGD 
Foco32RatBody Weight  IAGP  RGD 
Foco4RatBody Weight  IAGP  RGD 
Foco5RatBody Weight  IAGP  RGD 
Foco6RatBody Weight  IAGP  RGD 
Foco7RatBody Weight  IAGP  RGD 
Foco8RatBody Weight  IAGP  RGD 
Foco9RatBody Weight  IAGP  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bw127Ratincreased body weight  IDA  RGD 
Bw128Ratincreased body weight  IDA  RGD 
Bw129Ratincreased body weight  IDA  RGD 
Bw130Ratincreased body weight  IDA  RGD 
Bw131Ratincreased body weight  IDA  RGD 
Bw132Ratincreased body weight  IDA  RGD 
Bw133Ratincreased body weight  IDA  RGD 
Bw134Ratincreased body weight  IDA  RGD 
Bw135Ratincreased body weight  IDA  RGD 
Bw136Ratincreased body weight  IDA  RGD 
Bw137Ratincreased body weight  IDA  RGD 
Bw138Ratincreased body weight  IDA  RGD 
Bw139Ratincreased body weight  IDA  RGD 
Bw140Ratincreased body weight  IDA  RGD 
Bw141Ratincreased body weight  IDA  RGD 
Bw142Ratincreased body weight  IDA  RGD 
Foco10Ratincreased body weight  IDA  RGD 
Foco11Ratincreased body weight  IDA  RGD 
Foco12Ratincreased body weight  IDA  RGD 
Foco13Ratincreased body weight  IDA  RGD 
Foco14Ratincreased body weight  IDA  RGD 
Foco15Ratincreased body weight  IDA  RGD 
Foco16Ratincreased body weight  IDA  RGD 
Foco17Ratincreased body weight  IDA  RGD 
Foco18Ratincreased body weight  IDA  RGD 
Foco19Ratincreased body weight  IDA  RGD 
Foco20Ratincreased body weight  IDA  RGD 
Foco21Ratincreased body weight  IDA  RGD 
Foco22Ratincreased body weight  IDA  RGD 
Foco23Ratincreased body weight  IDA  RGD 
Foco24Ratincreased body weight  IDA  RGD 
Foco25Ratincreased body weight  IDA  RGD 
Foco26Ratincreased body weight  IDA  RGD 
Foco27Ratincreased body weight  IDA  RGD 
Foco28Ratincreased body weight  IDA  RGD 
Foco29Ratincreased body weight  IDA  RGD 
Foco3Ratincreased body weight  IDA  RGD 
Foco30Ratincreased body weight  IDA  RGD 
Foco31Ratincreased body weight  IDA  RGD 
Foco32Ratincreased body weight  IDA  RGD 
Foco4Ratincreased body weight  IDA  RGD 
Foco5Ratincreased body weight  IDA  RGD 
Foco6Ratincreased body weight  IDA  RGD 
Foco7Ratincreased body weight  IDA  RGD 
Foco8Ratincreased body weight  IDA  RGD 
Foco9Ratincreased body weight  IDA  RGD 
Foco10Ratincreased food intake  IDA  RGD 
Foco11Ratincreased food intake  IDA  RGD 
Foco12Ratincreased food intake  IDA  RGD 
Foco13Ratincreased food intake  IDA  RGD 
Foco14Ratincreased food intake  IDA  RGD 
Foco15Ratincreased food intake  IDA  RGD 
Foco16Ratincreased food intake  IDA  RGD 
Foco17Ratincreased food intake  IDA  RGD 
Foco18Ratincreased food intake  IDA  RGD 
Foco19Ratincreased food intake  IDA  RGD 
Foco20Ratincreased food intake  IDA  RGD 
Foco21Ratincreased food intake  IDA  RGD 
Foco22Ratincreased food intake  IDA  RGD 
Foco23Ratincreased food intake  IDA  RGD 
Foco24Ratincreased food intake  IDA  RGD 
Foco25Ratincreased food intake  IDA  RGD 
Foco26Ratincreased food intake  IDA  RGD 
Foco27Ratincreased food intake  IDA  RGD 
Foco28Ratincreased food intake  IDA  RGD 
Foco29Ratincreased food intake  IDA  RGD 
Foco3Ratincreased food intake  IDA  RGD 
Foco30Ratincreased food intake  IDA  RGD 
Foco31Ratincreased food intake  IDA  RGD 
Foco32Ratincreased food intake  IDA  RGD 
Foco4Ratincreased food intake  IDA  RGD 
Foco5Ratincreased food intake  IDA  RGD 
Foco6Ratincreased food intake  IDA  RGD 
Foco7Ratincreased food intake  IDA  RGD 
Foco8Ratincreased food intake  IDA  RGD 
Foco9Ratincreased food intake  IDA  RGD 
Objects Annotated

QTLs
Bw127  (Body weight QTL 127)
Bw128  (Body weight QTL 128)
Bw129  (Body weight QTL 129)
Bw130  (Body weight QTL 130)
Bw131  (Body weight QTL 131)
Bw132  (Body weight QTL 132)
Bw133  (Body weight QTL 133)
Bw134  (Body weight QTL 134)
Bw135  (Body weight QTL 135)
Bw136  (Body weight QTL 136)
Bw137  (Body weight QTL 137)
Bw138  (Body weight QTL 138)
Bw139  (Body weight QTL 139)
Bw140  (Body weight QTL 140)
Bw141  (Body weight QTL 141)
Bw142  (Body weight QTL 142)
Foco10  (Food consumption QTL 10)
Foco11  (Food consumption QTL 11)
Foco12  (Food consumption QTL 12)
Foco13  (Food consumption QTL 13)
Foco14  (Food consumption QTL 14)
Foco15  (Food consumption QTL 15)
Foco16  (Food consumption QTL 16)
Foco17  (Food consumption QTL 17)
Foco18  (Food consumption QTL 18)
Foco19  (Food consumption QTL 19)
Foco20  (Food consumption QTL 20)
Foco21  (Food consumption QTL 21)
Foco22  (Food consumption QTL 22)
Foco23  (Food consumption QTL 23)
Foco24  (Food consumption QTL 24)
Foco25  (Food consumption QTL 25)
Foco26  (Food consumption QTL 26)
Foco27  (Food consumption QTL 27)
Foco28  (Food consumption QTL 28)
Foco29  (Food consumption QTL 29)
Foco3  (Food consumption QTL 3)
Foco30  (Food consumption QTL 30)
Foco31  (Food consumption QTL 31)
Foco32  (Food consumption QTL 32)
Foco4  (Food consumption QTL 4)
Foco5  (Food consumption QTL 5)
Foco6  (Food consumption QTL 6)
Foco7  (Food consumption QTL 7)
Foco8  (Food consumption QTL 8)
Foco9  (Food consumption QTL 9)

Strains
F344/IcoCrlf  (NA)
LOU/NimrOlaHsd  (Louvain)

Objects referenced in this article
QTL Kcal2_m kilocalorie 2 (mouse) Mus musculus
QTL Alc10 Alcohol consumption QTL 10 Rattus norvegicus
QTL Alc12 Alcohol consumption QTL 12 Rattus norvegicus
QTL Alc5 Alcohol consumption QTL 5 Rattus norvegicus
QTL Alc6 Alcohol consumption QTL 6 Rattus norvegicus
QTL Alc9 Alcohol consumption QTL 9 Rattus norvegicus
QTL Niddm27 Non-insulin dependent diabetes mellitus QTL 27 Rattus norvegicus
QTL Niddm38 Non-insulin dependent diabetes mellitus QTL 38 Rattus norvegicus

Additional Information