RGD Reference Report - Dahl (S x R) rat congenic strain analysis confirms and defines a chromosome 17 spatial navigation quantitative trait locus to <10 Mbp. - Rat Genome Database

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Dahl (S x R) rat congenic strain analysis confirms and defines a chromosome 17 spatial navigation quantitative trait locus to <10 Mbp.

Authors: Herrera, VL  Pasion, KA  Tan, GA  Ruiz-Opazo, N 
Citation: Herrera VL, etal., PLoS One. 2013;8(2):e58280. doi: 10.1371/journal.pone.0058280. Epub 2013 Feb 28.
RGD ID: 7394833
Pubmed: (View Article at PubMed) PMID:23469157
DOI: Full-text: DOI:10.1371/journal.pone.0058280

A quantitative trait locus (QTL) linked with ability to find a platform in the Morris Water Maze (MWM) was located on chromosome 17 (Nav-5 QTL) using intercross between Dahl S and Dahl R rats. We developed two congenic strains, S.R17A and S.R17B introgressing Dahl R-chromosome 17 segments into Dahl S chromosome 17 region spanning putative Nav-5 QTL. Performance analysis of S.R17A, S.R17B and Dahl S rats in the Morris water maze (MWM) task showed a significantly decreased spatial navigation performance in S.R17B congenic rats when compared with Dahl S controls (P = 0.02). The S.R17A congenic segment did not affect MWM performance delimiting Nav-5 to the chromosome 17 65.02-74.66 Mbp region. Additional fine mapping is necessary to identify the specific gene variant accounting for Nav-5 effect on spatial learning and memory in Dahl rats.



Disease Annotations    

Phenotype Annotations    

Mammalian Phenotype
Objects Annotated

QTLs
Memor18  (Memory QTL 18)

Objects referenced in this article
Marker rs107058737 rs107058737 Rattus norvegicus
Marker rs105019230 rs105019230 Rattus norvegicus
Marker rs65978719 rs65978719 Rattus norvegicus
Marker rs106534785 rs106534785 Rattus norvegicus
QTL Memor5 Memory QTL 5 Rattus norvegicus

Additional Information