RGD Reference Report - TT polymorphism in rs2165241 and rs1048661 region in lysyl oxidase like-1 gene may have a role in stress urinary incontinence physiopathology. - Rat Genome Database

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TT polymorphism in rs2165241 and rs1048661 region in lysyl oxidase like-1 gene may have a role in stress urinary incontinence physiopathology.

Authors: Ozbek, E  Polat, EC  Ozcan, L  Otunctemur, A  Emrence, Z  Ustek, D 
Citation: Ozbek E, etal., J Obstet Gynaecol Res. 2013 Jan;39(1):237-42. doi: 10.1111/j.1447-0756.2012.01942.x. Epub 2012 Jul 6.
RGD ID: 7394729
Pubmed: (View Article at PubMed) PMID:22765198
DOI: Full-text: DOI:10.1111/j.1447-0756.2012.01942.x

AIM: In experimental studies, lysyl oxidase like-1 (LOX-L1) (-/-) mice were shown to have similar pelvic floor dysfunction to female rats. LOX-L1 levels in endopelvic fascia decrease as a result of increasing births in women with pelvic prolapse. For these reasons, we investigated the LOX-L1 gene polymorphism, which has an important role in connective tissue and collagenous metabolism in stress urinary incontinence (SUI). MATERIALS AND METHODS: A total of 87 women with SUI who underwent normal vaginal delivery and 87 controls were involved in the study. Single nucleotide gene polymorphisms in LOX-L1's rs1048661, G>T, pArg141Leu, Exon-1 SmaI; rs3825942, C>T, pGly153Asp, Hinf-1 and rs2165241, C>T, Intron-1 BsrI regions were searched. The results were statistically compared as alleles with 3x2 chi(2) -test. Results: A total of 32 (34%) GG, 20 (21%) GT, 42 (45%) TT, 32 (37%) GG, 43 (39%) GT, 21 (24%) TT polymorphisms in rs1048661; 30 (36%) CC, 16 (19%) CT, 37 (45%) TT, 41 (59%) CC, 15 (22%) CT, 13 (19%) TT polymorphisms in rs2165241; and 63 (72%) CC, 21 (24%) CT, 3 (4%) TT; 48 (6%) CC, 22 (30%) CT, 3 (4%) TT polymorphisms in rs3825942 were found in patients and the control group, respectively. In patients, the TT polymorphism in the rs1048661 and rs2165241 region were found to be significant. CONCLUSIONS: The homozygote TT polymorphism in the rs1048661 and rs2165241 region of LOX-L1 gene may be responsible from SUI physiopathology.



Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Loxl1  (lysyl oxidase-like 1)

Genes (Mus musculus)
Loxl1  (lysyl oxidase-like 1)

Genes (Homo sapiens)
LOXL1  (lysyl oxidase like 1)


Additional Information