RGD Reference Report - The R-spondin family of proteins: emerging regulators of WNT signaling. - Rat Genome Database

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The R-spondin family of proteins: emerging regulators of WNT signaling.

Authors: Jin, YR  Yoon, JK 
Citation: Jin YR and Yoon JK, Int J Biochem Cell Biol. 2012 Dec;44(12):2278-87. doi: 10.1016/j.biocel.2012.09.006. Epub 2012 Sep 13.
RGD ID: 7387232
Pubmed: PMID:22982762   (View Abstract at PubMed)
PMCID: PMC3496018   (View Article at PubMed Central)
DOI: DOI:10.1016/j.biocel.2012.09.006   (Journal Full-text)

Recently, the R-spondin (RSPO) family of proteins has emerged as important regulators of WNT signaling. Considering the wide spectrum of WNT signaling functions in normal biological processes and disease conditions, there has been a significantly growing interest in understanding the functional roles of RSPOs in multiple biological processes and determining the molecular mechanisms by which RSPOs regulate the WNT signaling pathway. Recent advances in the RSPO research field revealed some of the in vivo functions of RSPOs and provided new information regarding the mechanistic roles of RSPO activity in regulation of WNT signaling. Herein, we review recent progress in RSPO research with an emphasis on signaling mechanisms and biological functions.


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