RGD Reference Report - Increased neurodegeneration during ageing in mice lacking high-affinity nicotine receptors. - Rat Genome Database

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Increased neurodegeneration during ageing in mice lacking high-affinity nicotine receptors.

Authors: Zoli, M  Picciotto, MR  Ferrari, R  Cocchi, D  Changeux, JP 
Citation: Zoli M, etal., EMBO J 1999 Mar 1;18(5):1235-44.
RGD ID: 737811
Pubmed: PMID:10064590   (View Abstract at PubMed)
PMCID: PMC1171214   (View Article at PubMed Central)
DOI: DOI:10.1093/emboj/18.5.1235   (Journal Full-text)

We have examined neuroanatomical, biochemical and endocrine parameters and spatial learning in mice lacking the beta2 subunit of the nicotinic acetylcholine receptor (nAChR) during ageing. Aged beta2(-/-) mutant mice showed region-specific alterations in cortical regions, including neocortical hypotrophy, loss of hippocampal pyramidal neurons, astro- and microgliosis and elevation of serum corticosterone levels. Whereas adult mutant and control animals performed well in the Morris maze, 22- to 24-month-old beta2(-/-) mice were significantly impaired in spatial learning. These data show that beta2 subunit-containing nAChRs can contribute to both neuronal survival and maintenance of cognitive performance during ageing. beta2(-/-) mice may thus serve as one possible animal model for some of the cognitive deficits and degenerative processes which take place during physiological ageing and in Alzheimer's disease, particularly those associated with dysfunction of the cholinergic system.

Objects referenced in this article
Gene CHRNB2 cholinergic receptor nicotinic beta 2 subunit Homo sapiens
Gene Chrnb2 cholinergic receptor nicotinic beta 2 subunit Mus musculus
Gene Chrnb2 cholinergic receptor nicotinic beta 2 subunit Rattus norvegicus

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