RGD Reference Report - Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3. - Rat Genome Database

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Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3.

Authors: Ushikubi, F  Segi, E  Sugimoto, Y  Murata, T  Matsuoka, T  Kobayashi, T  Hizaki, H  Tuboi, K  Katsuyama, M  Ichikawa, A  Tanaka, T  Yoshida, N  Narumiya, S 
Citation: Ushikubi F, etal., Nature 1998 Sep 17;395(6699):281-4.
RGD ID: 737727
Pubmed: PMID:9751056   (View Abstract at PubMed)
DOI: DOI:10.1038/26233   (Journal Full-text)

Fever, a hallmark of disease, is elicited by exogenous pyrogens, that is, cellular components, such as lipopolysaccharide (LPS), of infectious organisms, as well as by non-infectious inflammatory insults. Both stimulate the production of cytokines, such as interleukin (IL)-1beta, that act on the brain as endogenous pyrogens. Fever can be suppressed by aspirin-like anti-inflammatory drugs. As these drugs share the ability to inhibit prostaglandin biosynthesis, it is thought that a prostaglandin is important in fever generation. Prostaglandin E2 (PGE2) may be a neural mediator of fever, but this has been much debated. PGE2 acts by interacting with four subtypes of PGE receptor, the EP1, EP2, EP3 and EP4 receptors. Here we generate mice lacking each of these receptors by homologous recombination. Only mice lacking the EP3 receptor fail to show a febrile response to PGE2 and to either IL-1beta or LPS. Our results establish that PGE2 mediates fever generation in response to both exogenous and endogenous pyrogens by acting at the EP3 receptor.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PTGER3HumanFever  ISOPtger3 (Mus musculus) RGD 
Ptger3RatFever  ISOPtger3 (Mus musculus) RGD 
Ptger3MouseFever  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ptger3  (prostaglandin E receptor 3)

Genes (Mus musculus)
Ptger3  (prostaglandin E receptor 3 (subtype EP3))

Genes (Homo sapiens)
PTGER3  (prostaglandin E receptor 3)

Objects referenced in this article
Gene Ptger1 prostaglandin E receptor 1 (subtype EP1) Mus musculus

Additional Information