RGD Reference Report - Genetic susceptibility to Graves' ophthalmopathy: The role of polymorphisms in anti-inflammatory cytokine genes. - Rat Genome Database

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Genetic susceptibility to Graves' ophthalmopathy: The role of polymorphisms in anti-inflammatory cytokine genes.

Authors: Khalilzadeh, O  Anvari, M  Esteghamati, A  Momen-Heravi, F  Rashidi, A  Amiri, HM  Tahvildari, M  Mahmoudi, M  Amirzargar, A 
Citation: Khalilzadeh O, etal., Ophthalmic Genet. 2010 Dec;31(4):215-20. doi: 10.3109/13816810.2010.515648.
RGD ID: 7364859
Pubmed: (View Article at PubMed) PMID:21067483
DOI: Full-text: DOI:10.3109/13816810.2010.515648

BACKGROUND: Various polymorphisms occur in cytokine genes involved in inflammatory processes in Graves' ophthalmopathy (GO). Anti-inflammatory cytokines such as transforming growth factor- beta (TGF-beta), interleukin-10 (IL-10) and interleukin-4 (IL-4) are among those believed to be involved in the disease process. In this study, we investigated the association between 8 polymorphisms within the mentioned cytokines and GO. METHODS: The following polymorphisms were studied in 50 patients with GO, 57 Graves' patients without GO and 140 healthy individuals using polymerase chain reaction with sequence-specific primers: TGF-beta (+869C/T, +915G/C), IL-10 (-1082A/G, -819C/T, -592C/A) and IL-4 (-1098T/G, -590T/C, -33C/T). A corrected p value less than 0.05 was considered statistically significant. RESULTS: The TGF-beta +915C allele (Odds Ratio [OR] = 2.20) and CC genotype (OR = 7.50) as well as +869C allele (OR = 2.21) showed significant correlations with GO. Regarding IL-4 polymorphisms, the -1098G allele (OR = 2.09) and GG genotype (OR = 7.49), and the -33T allele (OR = 2.05) and TT genotype (OR = 4.00) were significantly associated with GO. The IL-10 -819TT genotype (OR = 5.00) was significantly correlated with GO. CONCLUSION: This is the first study to show that polymorphisms in anti-inflammatory cytokine genes are associated with susceptibility to GO.



Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Il10  (interleukin 10)

Genes (Mus musculus)
Il10  (interleukin 10)

Genes (Homo sapiens)
IL10  (interleukin 10)


Additional Information