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An association of interleukin-10 gene polymorphisms with Graves' disease in two Chinese populations.

Authors: Liu, N  Lu, H  Tao, F  Guo, T  Liu, C  Cui, B  Ning, G 
Citation: Liu N, etal., Endocrine. 2011 Aug;40(1):90-4. doi: 10.1007/s12020-011-9444-7. Epub 2011 Mar 18.
Pubmed: (View Article at PubMed) PMID:21424183
DOI: Full-text: DOI:10.1007/s12020-011-9444-7

Graves' disease (GD) is a common autoimmune disorder with a genetic predisposition. The cytokine interleukin-10 (IL-10) has a central role in mediating inflammation, which may affect the outcome of the patients with GD. To elucidate the impact of IL-10 gene polymorphisms, we performed a two-stage case-control association study of five single-nucleotide polymorphisms (SNPs) within the IL-10 gene as well as a meta-analysis of two SNP's rs1800896 and rs1800872 covering three previous studies from Iran, Taiwan, and the United Kingdom. The five SNPs were genotyped by SNPstream Genotyping and Taqman PCR. There was a significant increase of G allele of rs1800896 in the two cohorts (P (allele) = 2.6 x 10(-4) and 0.0082 for cohort Shanghai and Xiamen, respectively) compared with the controls. The meta-analysis showed the risk-increasing effects for the G allele of rs1800896 in GD (OR = 1.88; P < 0.00001). The allele and haplotype analysis results suggested that the polymorphisms of IL-10 were associated with GD susceptibility in the Chinese population.

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RGD ID: 7364858
Created: 2013-10-03
Species: All species
Last Modified: 2013-10-03
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.