RGD Reference Report - Interleukin 10 deficiency attenuates induction of anti-TSH receptor antibodies and hyperthyroidism in a mouse Graves' model. - Rat Genome Database

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Interleukin 10 deficiency attenuates induction of anti-TSH receptor antibodies and hyperthyroidism in a mouse Graves' model.

Authors: Ueki, I  Abiru, N  Kawagoe, K  Nagayama, Y 
Citation: Ueki I, etal., J Endocrinol. 2011 Jun;209(3):353-7. doi: 10.1530/JOE-11-0129. Epub 2011 Apr 7.
RGD ID: 7364857
Pubmed: PMID:21474590   (View Abstract at PubMed)
DOI: DOI:10.1530/JOE-11-0129   (Journal Full-text)

Experimental Graves'-like hyperthyroidism can be induced in susceptible mouse strains by repetitive immunizations with recombinant adenovirus expressing the human full-length TSH receptor (TSHR) or its A-subunit. Previous studies have shown that splenocytes from immunized mice produce interferon (IFN)-gamma and interleukin (IL) 10 in response to antigen stimulation in an in vitro T cell recall assay. Although IFN-gamma is now well known to be essential for disease induction, the role(s) played by IL10 are unknown. Therefore, this study was conducted to clarify the significance of endogenous IL10 in the pathogenesis of experimental Graves' disease using IL10 deficient (IL10(-/-)) mice. Our results show that T cell response was augmented when estimated by their antigen-specific secretion of the key cytokine IFN-gamma, but B cell function was dampened, that is, anti-TSHR antibody titers were decreased in IL10(-/-) mice, resulting in a lower incidence of Graves' hyperthyroidism (54% in IL10(+/+) vs 25% in IL10(-/-)). Thus, in addition to IFN-gamma, these data clarified the role of IL10 for optimizing anti-TSHR antibody induction and eliciting Graves' hyperthyroidism in our Graves' mouse model.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hyperthyroidism  ISOIl10 (Mus musculus)7364857; 7364857associated with Graves DiseaseRGD 
hyperthyroidism  IMP 7364857associated with Graves DiseaseRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il10  (interleukin 10)

Genes (Mus musculus)
Il10  (interleukin 10)

Genes (Homo sapiens)
IL10  (interleukin 10)


Additional Information