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Effects of normal saline and selenium-enriched hot spring water on experimentally induced rhinosinusitis in rats.

Authors: Kim, DH  Yeo, SW 
Citation: Kim DH and Yeo SW, Int J Pediatr Otorhinolaryngol. 2013 Jan;77(1):117-22. doi: 10.1016/j.ijporl.2012.10.008. Epub 2012 Nov 3.
Pubmed: (View Article at PubMed) PMID:23131200
DOI: Full-text: DOI:10.1016/j.ijporl.2012.10.008

OBJECTIVE: This prospective, randomized, and controlled study examined the effects of normal saline and selenium-enriched hot spring water on experimentally induced rhinosinusitis in rats. METHODS: The study comprised two control groups (untreated and saline-treated) and three experimental groups of Sprague Dawley rats. The experimental groups received an instillation of lipopolysaccharide (LPS) only, LPS+normal saline (LPS/saline), or LPS+selenium-enriched hot spring water (LPS/selenium). Histopathological changes were identified using hematoxylin-eosin staining. Leakage of exudate was identified using fluorescence microscopy. Microvascular permeability was measured using the Evans blue dye technique. Expression of the Muc5ac gene was measured using reverse transcription-polymerase chain reaction. RESULTS: Mucosal edema and expression of the Muc5ac gene were significantly lower in the LPS/saline group than in the LPS group. Microvascular permeability, mucosal edema, and expression of the Muc5ac gene were significantly lower in the LPS/selenium group than in the LPS group. Mucosal edema was similar in the LPS/selenium group and LPS/saline group, but capillary permeability and Muc5ac expression were lower in the LPS/selenium group. CONCLUSIONS: This study shows that normal saline and selenium-enriched hot spring water reduce inflammatory activity and mucus hypersecretion in LPS-induced rhinosinusitis in rats.

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RGD Object Information
RGD ID: 7349403
Created: 2013-09-24
Species: All species
Last Modified: 2013-09-24
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.