RGD Reference Report - Effects of cerium oxide nanoparticles on PC12 neuronal-like cells: proliferation, differentiation, and dopamine secretion. - Rat Genome Database
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Effects of cerium oxide nanoparticles on PC12 neuronal-like cells: proliferation, differentiation, and dopamine secretion.

Authors: Ciofani, G  Genchi, GG  Liakos, I  Cappello, V  Gemmi, M  Athanassiou, A  Mazzolai, B  Mattoli, V 
Citation: Ciofani G, etal., Pharm Res. 2013 Aug;30(8):2133-45. doi: 10.1007/s11095-013-1071-y. Epub 2013 May 10.
RGD ID: 7349328
Pubmed: (View Article at PubMed) PMID:23661146
DOI: Full-text: DOI:10.1007/s11095-013-1071-y

PURPOSE: Oxidative stress has been found to play a key role in several diseases, that range from cancer to neurodegenerative disorders. Besides traditional anti-oxidant agents, in recent years much attention has been focused on nanotechnological solutions, including cerium oxide nanoparticles (nanoceria). METHODS: Thanks to its extraordinary catalytic properties, nanoceria mimics the activity of superoxide dismutase and of catalase, therefore acting as a reactive oxygen species (ROS) scavenger in many biological contexts. In this paper, we report on nanoceria interactions with PC12 cell line, that represents a valuable model for many features of central dopaminergic neurons. RESULTS: Nanoceria confirmed a strong anti-ROS action but, most interestingly, also showed beneficial effects on both cell differentiation and dopamine production. CONCLUSIONS: Even if deeper examinations will be necessary in order to better clarify the mechanisms at the base of the documented effects, nanoceria demonstrated a significant potential as pharmacological agent in the treatment of neurological disorders.

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