RGD Reference Report - Female sterility in mice lacking the basigin gene, which encodes a transmembrane glycoprotein belonging to the immunoglobulin superfamily. - Rat Genome Database

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Female sterility in mice lacking the basigin gene, which encodes a transmembrane glycoprotein belonging to the immunoglobulin superfamily.

Authors: Kuno, N  Kadomatsu, K  Fan, QW  Hagihara, M  Senda, T  Mizutani, S  Muramatsu, T 
Citation: Kuno N, etal., FEBS Lett 1998 Mar 27;425(2):191-4.
RGD ID: 734663
Pubmed: PMID:9559645   (View Abstract at PubMed)

Basigin (Bsg) is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. Bsg knock-out mice exhibit infertility of both sexes. Based on limited results, defective implantation has been considered to be the cause of the female infertility. We demonstrate here that disruption of the Bsg gene produces the failure of female reproductive processes including not only implantation but also fertilization. Bsg mRNA expression in cumulus cells and basolateral localization of the Bsg protein in the endometrial epithelium further support the importance of Bsg in these processes.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Female Infertility  ISOBsg (Mus musculus)734663; 734663 RGD 
Female Infertility  IMP 734663 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Bsg  (basigin (Ok blood group))

Genes (Mus musculus)
Bsg  (basigin)

Genes (Homo sapiens)
BSG  (basigin (Ok blood group))


Additional Information