RGD Reference Report - Role of the mouse ank gene in control of tissue calcification and arthritis. - Rat Genome Database

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Role of the mouse ank gene in control of tissue calcification and arthritis.

Authors: Ho, AM  Johnson, MD  Kingsley, DM 
Citation: Ho AM, etal., Science 2000 Jul 14;289(5477):265-70.
RGD ID: 734569
Pubmed: PMID:10894769   (View Abstract at PubMed)

Mutation at the mouse progressive ankylosis (ank) locus causes a generalized, progressive form of arthritis accompanied by mineral deposition, formation of bony outgrowths, and joint destruction. Here, we show that the ank locus encodes a multipass transmembrane protein (ANK) that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. A highly conserved gene is present in humans and other vertebrates. These results identify ANK-mediated control of pyrophosphate levels as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ANKHHumanarthritis  ISOAnk (Mus musculus) RGD 
AnkMousearthritis  IMP  RGD 
AnkhRatarthritis  ISOAnk (Mus musculus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ankh  (ANKH inorganic pyrophosphate transport regulator)

Genes (Mus musculus)
Ank  (progressive ankylosis)

Genes (Homo sapiens)
ANKH  (ANKH inorganic pyrophosphate transport regulator)


Additional Information