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AIM-1: a mammalian midbody-associated protein required for cytokinesis.

Authors: Terada, Y  Tatsuka, M  Suzuki, F  Yasuda, Y  Fujita, S  Otsu, M 
Citation: Terada Y, etal., EMBO J 1998 Feb 2;17(3):667-76.
Pubmed: (View Article at PubMed) PMID:9450992
DOI: Full-text: DOI:10.1093/emboj/17.3.667

Mitosis is a highly coordinated process that assures the fidelity of chromosome segregation. Errors in this process result in aneuploidy which can lead to cell death or oncogenesis. In this paper we describe a putative mammalian protein kinase, AIM-1 (Aurora and Ipl1-like midbody-associated protein), related to Drosophila Aurora and Saccharomyces cerevisiae Ipl1, both of which are required for chromosome segregation. AIM-1 message and protein accumulate at G2/M phase. The protein localizes at the equator of central spindles during late anaphase and at the midbody during telophase and cytokinesis. Overexpression of kinase-inactive AIM-1 disrupts cleavage furrow formation without affecting nuclear division. Furthermore, cytokinesis frequently fails, resulting in cell polyploidy and subsequent cell death. These results strongly suggest that AIM-1 is required for proper progression of cytokinesis in mammalian cells.


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RGD Object Information
RGD ID: 730040
Created: 2003-12-01
Species: All species
Last Modified: 2006-04-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.