RGD Reference Report - Developmental regulation and possible alternative cleavage of presenilin 1 in the rat retina. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Developmental regulation and possible alternative cleavage of presenilin 1 in the rat retina.

Authors: Bresciani, LG  Walsh, DT  Gentleman, SM  Jen, LS 
Citation: Bresciani LG, etal., Mol Cell Neurosci 2002 Oct;21(2):239-49.
RGD ID: 729595
Pubmed: PMID:12401445   (View Abstract at PubMed)

Presenilin 1 (PS1) is a multitransmembrane protein well known for being mutated in most cases of familial Alzheimer's disease. Although its pathological effect is clear, its biological functions are not yet fully understood, but it appears to be involved in development and apoptosis. To investigate the role of PS1 in developmental processes we have studied the expression and proteolytic processing of this protein in the developing rat retina. PS1 appears to be developmentally regulated in the retina, and the pattern of PS1 immunoreactivity is consistent with a role in retinal lamination and pattern formation. Interestingly, no correlation was observed between PS1-positive cells and cells undergoing programmed cell death, suggesting that PS1 does not play a role in apoptosis occurring during this period. Moreover, we observed a change in the pattern of PS1 proteolytic fragments suggestive of a novel alternative cleavage site in the PS1 molecule.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
neural retina development  IEP 729595 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Psen1  (presenilin 1)

Objects referenced in this article
Gene PSEN1 presenilin 1 Homo sapiens
Gene Psen1 presenilin 1 Mus musculus

Additional Information