RGD Reference Report - Deleted in Colorectal Cancer (DCC) encodes a netrin receptor. - Rat Genome Database

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Deleted in Colorectal Cancer (DCC) encodes a netrin receptor.

Authors: Keino-Masu, K  Masu, M  Hinck, L  Leonardo, ED  Chan, SS  Culotti, JG  Tessier-Lavigne, M 
Citation: Keino-Masu K, etal., Cell 1996 Oct 18;87(2):175-85.
RGD ID: 729062
Pubmed: PMID:8861902   (View Abstract at PubMed)

The guidance of developing axons in the nervous system is mediated partly by diffusible chemoattractants secreted by axonal target cells. Netrins are chemoattractants for commissural axons in the vertebrate spinal cord, but the mechanisms through which they produce their effects are unknown. We show that Deleted in Colorectal Cancer (DCC), a transmembrane protein of the immunoglobulin superfamily, is expressed on spinal commissural axons and possesses netrin-1-binding activity. Moreover, an antibody to DCC selectively blocks the netrin-1-dependent outgrowth of commissural axons in vitro. These results indicate that DCC is a receptor or a component of a receptor that mediates the effects of netrin-1 on commissural axons, and they complement genetic evidence for interactions between DCC and netrin homologs in C. elegans and Drosophila.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
DccRataxon guidance  IMP  RGD 

Molecular Function

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
DccRatnetrin receptor activity  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Dcc  (DCC netrin 1 receptor)

Objects referenced in this article
Gene Neo1 neogenin 1 Rattus norvegicus

Additional Information