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Cloning by functional expression of a member of the glutamate receptor family.

Authors: Hollmann, M  O'Shea-Greenfield, A  Rogers, SW  Heinemann, S 
Citation: Hollmann M, etal., Nature 1989 Dec 7;342(6250):643-8.
Pubmed: (View Article at PubMed) PMID:2480522
DOI: Full-text: DOI:10.1038/342643a0

We have isolated a complementary DNA clone by screening a rat brain cDNA library for expression of kainate-gated ion channels in Xenopus oocytes. The cDNA encodes a single protein of relative molecular mass (Mr) 99,800 which on expression in oocytes forms a functional ion channel possessing the electrophysiological and pharmacological properties of the kainate subtype of the glutamate receptor family in the mammalian central nervous system.

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RGD ID: 728518
Created: 2003-11-19
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Last Modified: 2003-11-19
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