RGD Reference Report - Cloning by functional expression of a member of the glutamate receptor family. - Rat Genome Database

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Cloning by functional expression of a member of the glutamate receptor family.

Authors: Hollmann, M  O'Shea-Greenfield, A  Rogers, SW  Heinemann, S 
Citation: Hollmann M, etal., Nature 1989 Dec 7;342(6250):643-8.
RGD ID: 728518
Pubmed: PMID:2480522   (View Abstract at PubMed)
DOI: DOI:10.1038/342643a0   (Journal Full-text)

We have isolated a complementary DNA clone by screening a rat brain cDNA library for expression of kainate-gated ion channels in Xenopus oocytes. The cDNA encodes a single protein of relative molecular mass (Mr) 99,800 which on expression in oocytes forms a functional ion channel possessing the electrophysiological and pharmacological properties of the kainate subtype of the glutamate receptor family in the mammalian central nervous system.

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
glutamate-gated receptor activity enablesIDA 728518PMID:2480522UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Gria1  (glutamate ionotropic receptor AMPA type subunit 1)


Additional Information