RGD Reference Report - Molecular cloning and sequencing of cDNA encoding the phosphatidylinositol kinase from rat brain. - Rat Genome Database

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Molecular cloning and sequencing of cDNA encoding the phosphatidylinositol kinase from rat brain.

Authors: Yamakawa, A  Nishizawa, M  Fujiwara, KT  Kawai, S  Kawasaki, H  Suzuki, K  Takenawa, T 
Citation: Yamakawa A, etal., J Biol Chem 1991 Sep 15;266(26):17580-3.
RGD ID: 728505
Pubmed: PMID:1654331   (View Abstract at PubMed)

A complementary DNA (cDNA) clone that encodes phosphatidylinositol 4-kinase (PI 4-kinase) was isolated from a rat brain cDNA library. The deduced amino acid sequence of 697 residues revealed that the protein contains two putative transmembrane sequences and that the N-terminal part of the protein has several sequences representing potential phosphorylation sites for cAMP- and calmodulin-dependent kinase. The C-terminal region is probably a phosphotransferase domain homologous to the kinase region of protein kinase family proteins. Specific antibody against the protein expressed in Escherichia coli successfully immunoprecipitated rat brain PI 4-kinase. The messenger RNA for PI 4-kinase was found predominantly in brain and rat neural cell lines. This PI kinase may play a specific role in neural signal transduction.

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Gene Acsl6 acyl-CoA synthetase long-chain family member 6 Rattus norvegicus

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