RGD Reference Report - Substitution mapping of a blood pressure quantitative trait locus to a 2.73 Mb region on rat chromosome 1. - Rat Genome Database

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Substitution mapping of a blood pressure quantitative trait locus to a 2.73 Mb region on rat chromosome 1.

Authors: Joe, B  Garrett, MR  Dene, H  Rapp, JP 
Citation: Joe B, etal., J Hypertens 2003 Nov;21(11):2077-84.
RGD ID: 728381
Pubmed: PMID:14597851   (View Abstract at PubMed)
DOI: DOI:10.1097/01.hjh.0000098124.00558.09   (Journal Full-text)

SUMMARY: OBJECTIVE To improve the localization of a blood pressure quantitative trait locus (BP QTL) on rat chromosome (RNO) 1.METHODS Congenic substrains were derived from the progenitor congenic strains S.LEW(D1Mco4X1) and S.LEW(D1Mco4X5) which previously localized a BP QTL (region 2) to a 17cM interval on RNO1. The newly developed congenic substrains, along with control Dahl salt-sensitive (S) rats were fed a 2% NaCl diet for 24 days before their BP was compared by both tail-cuff and radiotelemetry methods.RESULTS By comparing BP of these congenic substrains to that of S rats, we have refined the location of the BP QTL2 region to a 2.73 Mb genomic interval that contains 19 annotated genes in the latest rat genome assembly (version 2.1). Slc9a3, the gene encoding the Na+/H+ exchanger 3, originally a candidate gene in the BP QTL2 region, is excluded based on its map location.CONCLUSION Substitution mapping was used to reduce a BP QTL on RNO1 from 17 centimorgans (cM) to approximately 1.4 cM (= 2.73 Mb). This region now contains 19 annotated rat candidate genes.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hypertension  IDA 728381 RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
increased systemic arterial blood pressure  QTM 728381 RGD 

Objects Annotated

QTLs
Bp153  (Blood pressure QTL 153)

Objects referenced in this article
Strain SS.LEW-(D1Mco4-D1Rat18)/Mco null Rattus norvegicus
Strain SS.LEW-(D1Mco75-D1Rat18)/Mco null Rattus norvegicus
Strain SS.LEW-(D1Mco8-D1Rat213)/Mco null Rattus norvegicus
Strain SS.LEW-(D1Uia8-D1Rat18)/Mco null Rattus norvegicus
Strain SS.LEW-(D1Uia8-D1Rat211)/Mco null Rattus norvegicus

Additional Information