RGD Reference Report - A novel CYP3 gene from female rats. - Rat Genome Database

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A novel CYP3 gene from female rats.

Authors: Strotkamp, D  Roos, PH  Hanstein, WG 
Citation: Strotkamp D, etal., Biochim Biophys Acta 1995 Feb 21;1260(3):341-4.
RGD ID: 728270
Pubmed: PMID:7873612   (View Abstract at PubMed)

A cDNA library constructed from adult female Sprague Dawley rat liver was screened with polyclonal anti CYP3A-IgG. One of the positive clones, cUT, was found to contain the complete coding sequence of a new gene more similar to hamster gene CYP3A10 (cDNA: 85%, deduced amino acid sequence: 79%) than to the known rat CYP3A genes (cDNA: 75-76%, amino acid sequences: 66-69%). The deduced sequence of the first 28 amino acids is identical to the N-terminus of the testosterone 6 beta-hydroxylase, 6 beta-2 (Nagata, K., Gonzalez, F.J., Yamazoe, Y. and Kato, R. (1990) J. Biochem. 107, 718-725). Northern blots show the presence of cUT mRNA in livers of adult female and male rats. The transcription of the new gene is enhanced in either sex by pregnenolone-alpha-carbonitrile, dexamethasone, phenobarbital, and triacetyloleandomycin, known inducers of CYP3A gene expression.

Objects referenced in this article
Gene Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 Rattus norvegicus

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