RGD Reference Report - Molecular cloning and sequencing of cDNA for rat cathepsin H. Homology in pro-peptide regions of cysteine proteinases. - Rat Genome Database

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Molecular cloning and sequencing of cDNA for rat cathepsin H. Homology in pro-peptide regions of cysteine proteinases.

Authors: Ishidoh, K  Imajoh, S  Emori, Y  Ohno, S  Kawasaki, H  Minami, Y  Kominami, E  Katunuma, N  Suzuki, K 
Citation: Ishidoh K, etal., FEBS Lett 1987 Dec 21;226(1):33-7.
RGD ID: 728259
Pubmed: PMID:3691815   (View Abstract at PubMed)

A cDNA for rat cathepsin H was isolated and sequenced. The deduced protein comprising 333 amino acid residues is composed of a typical signal sequence (21 residues), a pro-peptide region (92 residues) and a mature enzyme region (220 residues). The amino acid sequence in the pro-peptide region, in particular, residues Phe-(-41) to Ser-(-29) of cathepsin H, is highly homologous to the pro-peptide regions of other cysteine proteinases. This homologous region may play a role in the processing of cysteine proteinases.

Objects referenced in this article
Gene Ctsh cathepsin H Rattus norvegicus

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