RGD Reference Report - Primary structure and expression of beta 2: a novel subunit of neuronal nicotinic acetylcholine receptors. - Rat Genome Database

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Primary structure and expression of beta 2: a novel subunit of neuronal nicotinic acetylcholine receptors.

Authors: Deneris, ES  Connolly, J  Boulter, J  Wada, E  Wada, K  Swanson, LW  Patrick, J  Heinemann, S 
Citation: Deneris ES, etal., Neuron 1988 Mar;1(1):45-54.
RGD ID: 727608
Pubmed: PMID:3272154   (View Abstract at PubMed)

A new subunit, beta 2, of the neuronal nicotinic receptor family has been identified. This subunit has the structural features of a non-agonist-binding subunit. We provide evidence that beta 2 can substitute for the muscle beta 1 subunit to form a functional nicotinic receptor in Xenopus oocytes. Expression studies performed in oocytes have demonstrated that three different neuronal nicotinic acetylcholine receptors can be formed by the pairwise injection of beta 2 mRNA and each of the neuronal alpha subunit mRNAs. The beta 2 gene is expressed in PC12 cells and in areas of the central nervous system where the alpha 2, alpha 3, and alpha 4 genes are expressed. These results lead us to propose that the nervous system expresses diverse forms of neuronal nicotinic acetylcholine receptors by combining beta 2 subunits with different agonist-binding alpha subunits.

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Gene Chrnb2 cholinergic receptor nicotinic beta 2 subunit Rattus norvegicus

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