RGD Reference Report - Circadian rhythm of aromatic L-amino acid decarboxylase in the rat suprachiasmatic nucleus: gene expression and decarboxylating activity in clock oscillating cells. - Rat Genome Database

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Circadian rhythm of aromatic L-amino acid decarboxylase in the rat suprachiasmatic nucleus: gene expression and decarboxylating activity in clock oscillating cells.

Authors: Ishida, Y  Yokoyama, C  Inatomi, T  Yagita, K  Dong, X  Yan, L  Yamaguchi, S  Nagatsu, I  Komori, T  Kitahama, K  Okamura, H 
Citation: Ishida Y, etal., Genes Cells 2002 May;7(5):447-59.
RGD ID: 727571
Pubmed: (View Article at PubMed) PMID:12047348

BACKGROUND: Aromatic L-amino acid decarboxylase (AADC) is the enzyme responsible for the decarboxylation step in both the catecholamine and indoleamine synthetic pathways. In the brain, however, a group of AADC containing neurones is found outside the classical monoaminergic cell groups. Since such non-monoaminergic AADC is expressed abundantly in the suprachiasmatic nucleus (SCN), the mammalian circadian centre, we characterized the role of AADC in circadian oscillation. RESULTS: AADC gene expression was observed in neurones of the dorsomedial subdivision of the SCN and its dorsal continuant in the anterior hypothalamic area. These AADC neurones could uptake exogenously applied L-DOPA and formed dopamine. AADC was co-expressed with vasopressin and the clock gene Per1 in the neurones of the SCN. Circadian gene expression of AADC was observed with a peak at subjective day and a trough at subjective night. The circadian rhythm of AADC enzyme activity in the SCN reflects the expression of the gene. CONCLUSIONS: Non-monoaminergic AADC in the SCN is expressed in clock oscillating cells, and the decarboxylating activity of master clock cells are under the control of the circadian rhythm.

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Molecular Function

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Genes (Rattus norvegicus)
Ddc  (dopa decarboxylase)


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