RGD Reference Report - Neuroprotective effects of interleukin-6 on NMDA-induced rat retinal damage. - Rat Genome Database

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Neuroprotective effects of interleukin-6 on NMDA-induced rat retinal damage.

Authors: Inomata, Y  Hirata, A  Yonemura, N  Koga, T  Kido, N  Tanihara, H 
Citation: Inomata Y, etal., Biochem Biophys Res Commun 2003 Mar 7;302(2):226-32.
RGD ID: 727510
Pubmed: PMID:12604335   (View Abstract at PubMed)

This study shows that interleukin-6 (IL-6) combined with soluble interleukin-6 receptors (sIL-6R) modulates N-methyl-D-aspartate (NMDA)-induced retinal damage. Eyes pretreated with a combined injection of IL-6 and sIL-6R had NMDA administered into the vitreous cavity. Morphometric analysis and retrograde labeling analysis found that pretreatment with either IL-6 or sIL-6R alone did not bring about any neuroprotective effect. However, pretreatment with a combined administration of IL-6 and sIL-6R induced a significant neuroprotective effect against NMDA-induced retinal damage. Apoptotic changes in the retina were assessed by the TUNEL method. The results indicated that pretreatment with IL-6 combined with sIL-6R prevents NMDA-induced apoptosis. Western blotting studies demonstrated upregulation of gp130 expression in the NMDA-injected retina. Present studies suggest that IL-6 combined with sIL-6R provides a neuroprotective effect on NMDA-induced retinal damage.



Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Il6Ratinterleukin-6 receptor binding  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il6  (interleukin 6)

Objects referenced in this article
Gene Il6r interleukin 6 receptor Rattus norvegicus

Additional Information