RGD Reference Report - Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K(+) channel Kv2.1. - Rat Genome Database

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Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K(+) channel Kv2.1.

Authors: Sano, Y  Mochizuki, S  Miyake, A  Kitada, C  Inamura, K  Yokoi, H  Nozawa, K  Matsushime, H  Furuichi, K 
Citation: Sano Y, etal., FEBS Lett 2002 Feb 13;512(1-3):230-4.
RGD ID: 727345
Pubmed: PMID:11852086   (View Abstract at PubMed)

We report identification and characterization of Kv6.3, a novel member of the voltage-gated K(+) channel. Reverse transcriptase-polymerase chain reaction analysis indicated that Kv6.3 was highly expressed in the brain. Electrophysiological studies indicated that homomultimeric Kv6.3 did not yield a functional voltage-gated ion channel. When Kv6.3 and Kv2.1 were co-expressed, the heteromultimeric channels displayed the decreased rate of deactivation compared to the homomultimeric Kv2.1 channels. Immunoprecipitation studies indicated that Kv6.3 bound with Kv2.1 in co-transfected cells. These results indicate that Kv6.3 is a novel member of the voltage-gated K(+) channel which functions as a modulatory subunit.

Objects referenced in this article
Gene KCNG3 potassium voltage-gated channel modifier subfamily G member 3 Homo sapiens
Gene Kcng3 potassium voltage-gated channel modifier subfamily G member 3 Rattus norvegicus

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