RGD Reference Report - Mouse cathepsin M, a placenta-specific lysosomal cysteine protease related to cathepsins L and P. - Rat Genome Database

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Mouse cathepsin M, a placenta-specific lysosomal cysteine protease related to cathepsins L and P.

Authors: Sol-Church, K  Frenck, J  Mason, RW 
Citation: Sol-Church K, etal., Biochim Biophys Acta 2000 Apr 25;1491(1-3):289-94.
RGD ID: 727228
Pubmed: PMID:10760593   (View Abstract at PubMed)

The complete nucleotide sequence of a novel cathepsin cDNA derived from mouse placenta was determined and is termed cathepsin M. The predicted protein of 333 amino acid is a member of the family C1A proteases and is related to mouse cathepsins L and P. Mouse cathepsin M is highly expressed in placenta, whereas no detectable levels were found in lung, spleen, heart, brain, kidney, thymus, testicle, liver, or embryo. Phylogenic analyses of the sequences of human and mouse cathepsins show that cathepsin M is most closely related to cathepsins P and L. However, the differences are sufficiently large to indicate that the enzymes will be found in other species. This is in contrast to human cathepsins L and V, which probably resulted from a gene duplication after divergence of mammalian species.

Objects referenced in this article
Gene Ctsh cathepsin H Mus musculus
Gene Ctsj cathepsin J Mus musculus
Gene Ctsk cathepsin K Mus musculus
Gene Ctsl cathepsin L Mus musculus
Gene Ctsm cathepsin M Mus musculus
Gene Ctss cathepsin S Mus musculus
Gene Ctsm cathepsin M Rattus norvegicus

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