RGD Reference Report - Heat shock protein 70 gene polymorphisms are associated with paranoid schizophrenia in the Polish population. - Rat Genome Database

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Heat shock protein 70 gene polymorphisms are associated with paranoid schizophrenia in the Polish population.

Authors: Kowalczyk, M  Owczarek, A  Suchanek, R  Paul-Samojedny, M  Fila-Danilow, A  Borkowska, P  Kucia, K  Kowalski, J 
Citation: Kowalczyk M, etal., Cell Stress Chaperones. 2013 Jul 28.
RGD ID: 7257645
Pubmed: PMID:23893339   (View Abstract at PubMed)
PMCID: PMC3933617   (View Article at PubMed Central)
DOI: DOI:10.1007/s12192-013-0446-7   (Journal Full-text)

HSP70 genes have been considered as promising schizophrenia candidate genes based on their protective role in the central nervous system under stress conditions. In this study, we analyzed the potential implication of HSPA1A +190G/C, HSPA1B +1267A/G, and HSPA1L +2437T/C polymorphisms in the susceptibility to paranoid schizophrenia in a homogenous Caucasian Polish population. In addition, we investigated the association of the polymorphisms with the clinical variables of the disease. Two hundred and three patients with paranoid schizophrenia and 243 healthy controls were enrolled in the study. Polymorphisms of HSPA1A, -1B, and -1L genes were genotyped using the PCR-RFLP technique. Analyses were conducted in entire groups and in subgroups that were stratified according to gender. There were significant differences in the genotype and allele frequencies of HSPA1A polymorphism between the patients and controls. The +190CC genotype and +190C allele were over-represented in the patients and significantly increased the risk for developing schizophrenia (OR = 3.45 and OR = 1.61, respectively). Interestingly, such a risk was higher for females with the +190CC genotype than for males with the +190CC genotype (OR = 5.78 vs. OR = 2.76). We also identified the CGT haplotype as a risk haplotype for schizophrenia and demonstrated the effects of HSPA1A and HSPA1B genotypes on the psychopathology and age of onset. Our study provided the first evidence that the HSPA1A polymorphism may potentially increase the risk of developing paranoid schizophrenia. Further independent analyses in different populations to evaluate the role of gender are needed to replicate these results.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
paranoid schizophrenia susceptibilityIAGP 7257645DNA:SNP: :190G>C(human)RGD 
paranoid schizophrenia susceptibilityISOHSPA1A (Homo sapiens)7257645; 7257645DNA:SNP: :190G>C(human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Hspa1a  (heat shock protein family A (Hsp70) member 1A)

Genes (Mus musculus)
Hspa1a  (heat shock protein 1A)

Genes (Homo sapiens)
HSPA1A  (heat shock protein family A (Hsp70) member 1A)


Additional Information