RGD Reference Report - Inhibition of the CD40-CD40ligand pathway prevents murine membranous glomerulonephritis. - Rat Genome Database

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Inhibition of the CD40-CD40ligand pathway prevents murine membranous glomerulonephritis.

Authors: Biancone, L  Andres, G  Ahn, H  DeMartino, C  Stamenkovic, I 
Citation: Biancone L, etal., Kidney Int. 1995 Aug;48(2):458-68.
RGD ID: 7248720
Pubmed: PMID:7564113   (View Abstract at PubMed)

Several forms of glomerulonephritis are induced by antibodies against self or foreign antigens. Normal B lymphocyte antibody production requires T cell costimulatory signals provided in part by T cell surface expression of gp39/CD40ligand (CD40L) that engages the B cell receptor CD40 and induces B cell differentiation and immunoglobulin class switching. We assessed the effect of disrupting the CD40L-CD40 costimulatory pathway, using a CD40-Ig fusion protein, on the development of membranous glomerulonephritis (MGN) in the mouse. MGN is induced by mouse antibodies that recognize and bind to exogenously administered rabbit anti-mouse renal tubular brush border (RbAMBB) IgG immobilized in the glomerular capillary wall. MGN did not occur in nude mice, showing the need of the T cell function. C57Bl/10 mice immunized with RbAMBB and treated with CD40-Ig fusion protein displayed a delayed autologous response and absence of MGN lesions, while control fusion proteins failed to prevent the development of the disease. These observations provide evidence that disruption of the CD40-CD40L costimulatory pathway can prevent the development of MGN by suppressing T cell-dependent antibody production.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
membranous glomerulonephritis treatmentISOCd40lg (Mus musculus)7248720; 7248720 RGD 
membranous glomerulonephritis treatmentIMP 7248720 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cd40lg  (CD40 ligand)

Genes (Mus musculus)
Cd40lg  (CD40 ligand)

Genes (Homo sapiens)
CD40LG  (CD40 ligand)


Additional Information