RGD Reference Report - Quantitative trait loci with opposing blood pressure effects demonstrating epistasis on Dahl rat chromosome 3. - Rat Genome Database
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Quantitative trait loci with opposing blood pressure effects demonstrating epistasis on Dahl rat chromosome 3.

Authors: Palijan, A  Dutil, J  Deng, AY 
Citation: Palijan A, etal., Physiol Genomics 2003 Sep 29;15(1):1-8.
RGD ID: 724791
Pubmed: (View Article at PubMed) PMID:14517349
DOI: Full-text: DOI:10.1152/physiolgenomics.00084.2003

Our previous linkage studies indicated that there might be a blood pressure (BP) quantitative trait locus (QTL) on chromosome 3 (Chr 3) contrasting between the Dahl salt-sensitive (S) strain and the Lewis (LEW) strain. To prove and then to narrow down the segment containing this QTL, five congenic strains have been generated by replacing various segments of the S rats with the homologous segments of the LEW rats. They are designated as S.L1, S.L2, S.L3, S.L4, and S.L5, respectively. S.L2, S.L3, S.L4, and S.L5 are substrains of S.L1, i.e., they contain substitutions of smaller sections within the large fragment defined by S.L1. The construction of these congenic strains was facilitated by a genome-wide marker screening process. BPs of the rats were measured by telemetry. S.L2 and S.L3 shared a fragment of Chr 3 in common and both showed a BP-lowering effect, indicating the existence of "-BP" QTL alleles from LEW compared with S. In contrast, S.L4 involves a section with no overlap with either S.L2 or S.L3, and S.L4 showed a BP significantly higher than that of S rats, indicating the presence of "+BP" QTL alleles from LEW compared with S. Interestingly, the combined effect of the -BP QTL and +BP QTL alleles was "-" in S.L1, implying that the "-" QTL is epistatic to "+" QTL.

Annotation

Disease Annotations    
hypertension  (IAGP)

Phenotype Values via PhenoMiner

View PhenoMiner data from this reference here 

Objects Annotated

QTLs
Bp151  (Blood pressure QTL 151)
Bp152  (Blood pressure QTL 152)

Objects referenced in this article
0 D3Chm66 D3Chm66 All species
0 D3Chm30 D3Chm30 All species
0 D3Chm61 D3Chm61 All species
0 D3Chm32 D3Chm32 All species
0 D3Chm2 D3Chm2 All species
0 D3Chm11 D3Chm11 All species
0 D3Chm10 D3Chm10 All species
0 D3Chm42 D3Chm42 All species
0 D3Chm58 D3Chm58 All species
0 D3Chm76 D3Chm76 All species
0 D3Chm55 D3Chm55 All species
0 D3Chm12 D3Chm12 All species
0 D3Chm40 D3Chm40 All species
0 D3Chm29 D3Chm29 All species
0 D3Chm68 D3Chm68 All species
0 D3Chm62 D3Chm62 All species
0 D3Chm39 D3Chm39 All species
0 D3Chm34 D3Chm34 All species
0 D3Chm15 D3Chm15 All species
0 D3Chm25 D3Chm25 All species
0 D3Chm51 D3Chm51 All species
0 D3Chm78 D3Chm78 All species
0 D3Chm64 D3Chm64 All species
0 D3Chm3 D3Chm3 All species
0 D3Chm80 D3Chm80 All species
0 D3Chm8 D3Chm8 All species
0 D3Chm26 D3Chm26 All species
0 D3Chm22 D3Chm22 All species
0 D3Chm43 D3Chm43 All species
0 D3Chm57 D3Chm57 All species
0 D3Chm37 D3Chm37 All species
0 D3Chm41 D3Chm41 All species
0 D3Chm7 D3Chm7 All species
0 D3Chm72 D3Chm72 All species
0 D3Chm36 D3Chm36 All species
0 D3Chm65 D3Chm65 All species
0 D3Chm79 D3Chm79 All species
0 D3Chm54 D3Chm54 All species
0 D3Chm63 D3Chm63 All species
0 D3Chm49 D3Chm49 All species
0 D3Chm60 D3Chm60 All species
0 D3Chm50 D3Chm50 All species
0 D3Chm6 D3Chm6 All species
0 Bw181 Body weght QTL 181 All species
0 Kidm37 Kidney mass QTL 37 All species

Additional Information