RGD Reference Report - Regression of microalbuminuria in type 1 diabetes is associated with lower levels of urinary tubular injury biomarkers, kidney injury molecule-1, and N-acetyl-beta-D-glucosaminidase. - Rat Genome Database

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Regression of microalbuminuria in type 1 diabetes is associated with lower levels of urinary tubular injury biomarkers, kidney injury molecule-1, and N-acetyl-beta-D-glucosaminidase.

Authors: Vaidya, VS  Niewczas, MA  Ficociello, LH  Johnson, AC  Collings, FB  Warram, JH  Krolewski, AS  Bonventre, JV 
Citation: Vaidya VS, etal., Kidney Int. 2011 Feb;79(4):464-70. doi: 10.1038/ki.2010.404. Epub 2010 Oct 27.
RGD ID: 7246890
Pubmed: PMID:20980978   (View Abstract at PubMed)
PMCID: PMC3033751   (View Article at PubMed Central)
DOI: DOI:10.1038/ki.2010.404   (Journal Full-text)

Elevated urinary albumin excretion in patients with type 1 diabetes reverts to normoalbuminuria in a majority of patients but advances toward proteinuria in some. In order to gain valuable insights into the early pathophysiology of diabetic nephropathy we evaluated the association of kidney tubular injury biomarkers with changes in albuminuria in patients with type 1 diabetes mellitus. Urine levels of kidney injury molecule-1 (KIM-1), N-acetyl-beta-D-glucosaminidase (NAG), and some inflammatory markers were determined in 38 healthy individuals and 659 patients with type 1 diabetes mellitus having varying degrees of albuminuria. Urinary interleukin-6, CXCL10/IP-10, NAG, and KIM-1 levels were very low in healthy individuals, increased in type 1 patients with normoalbuminuria, and were highest in diabetic patients that had microalbuminuria. Low baseline concentrations of urinary KIM-1 and NAG both individually and collectively were significantly associated with the regression of microalbuminuria over the subsequent 2 years; an effect independent of clinical characteristics. Progression and regression of microalbuminuria were unrelated to urinary levels of interleukins 6 and 8, CXCL10/IP-10, and monocyte chemoattractant protein-1. Thus our results show that lower urinary KIM-1 and NAG levels were associated with the regression of microalbuminuria in type 1 diabetes mellitus. Hence, tubular dysfunction is a critical component of the early course of diabetic nephropathy.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HAVCR1HumanDiabetic Nephropathies disease_progressionIEP associated with Diabetes mellitus and Type 1RGD 
Havcr1RatDiabetic Nephropathies disease_progressionISOHAVCR1 (Homo sapiens)associated with Diabetes mellitus and Type 1RGD 
Havcr1MouseDiabetic Nephropathies disease_progressionISOHAVCR1 (Homo sapiens)associated with Diabetes mellitus and Type 1RGD 

Objects Annotated

Genes (Rattus norvegicus)
Havcr1  (hepatitis A virus cellular receptor 1)

Genes (Mus musculus)
Havcr1  (hepatitis A virus cellular receptor 1)

Genes (Homo sapiens)
HAVCR1  (hepatitis A virus cellular receptor 1)


Additional Information