RGD Reference Report - Confirmation of alcohol preference quantitative trait loci in the replicate high alcohol drinking and low alcohol drinking rat lines. - Rat Genome Database

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Confirmation of alcohol preference quantitative trait loci in the replicate high alcohol drinking and low alcohol drinking rat lines.

Authors: Foroud, T  Ritchotte, A  Spence, J  Liu, L  Lumeng, L  Li, TK  Carr, LG 
Citation: Foroud T, etal., Psychiatr Genet 2003 Sep;13(3):155-61.
RGD ID: 724636
Pubmed: PMID:12960747   (View Abstract at PubMed)
DOI: DOI:10.1097/01.ypg.0000066966.80715.2f   (Journal Full-text)

OBJECTIVE: Selective breeding has been employed to develop replicate high-alcohol-drinking (HAD1 and HAD2) and low-alcohol-drinking (LAD1 and LAD2) rat lines from the heterogeneous N/Nih rat. Within-family selection and a rotational breeding design were used to discourage inbreeding (Li et al., 1993). A genome screen was previously performed using 459 HAD1xLAD1 F2 progeny to identify quantitative trait loci (QTLs) on rat chromosomes 5, 10, 12 and 16 that contribute to alcohol preference and consumption in these non-inbred rat models of alcoholism. METHODS: To confirm these QTLs in the replicate lines, 16 HAD2 and 16 LAD2 rats were genotyped for microsatellite markers within each of these QTL intervals. RESULTS: Review of the genotypic data support confirmation of the QTLs on chromosomes 5 and 10; several markers in the QTL region display different alleles in the HAD2 and LAD2 rats, suggesting linkage disequilibrium between the microsatellite markers and the QTL. Although the QTL on chromosome 12 had the highest LOD score in the HAD1 and LAD1 studies, little evidence supported confirmation of this QTL based on the genotyped markers. CONCLUSIONS: Further evaluation of each of these QTL regions is ongoing in a sample of HAD2xLAD2 F2 progeny currently being generated that will be used to assess the evidence of linkage in each of these QTL regions.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Alc5Ratalcohol use disorder  IDA  RGD 
Alc7Ratalcohol use disorder  IDA  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Alc7Ratalcohol preference  QTM  RGD 
Objects Annotated

QTLs
Alc5  (Alcohol consumption QTL 5)
Alc7  (Alcohol consumption QTL 7)

Strains
Iusm:HAD1  (high-alcohol-drinking)
Iusm:LAD1  (low-alcohol-drinking)

Objects referenced in this article
QTL Alc4 Alcohol consumption QTL 4 Rattus norvegicus
Strain Iusm:HAD2 high-alcohol-drinking Rattus norvegicus
Strain Iusm:LAD2 low-alcohol-drinking Rattus norvegicus

Additional Information