RGD Reference Report - The cloning of a rat peptidoglycan recognition protein (PGRP) and its induction in brain by sleep deprivation. - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

The cloning of a rat peptidoglycan recognition protein (PGRP) and its induction in brain by sleep deprivation.

Authors: Rehman, A  Taishi, P  Fang, J  Majde, JA  Krueger, JM 
Citation: Rehman A, etal., Cytokine 2001 Jan 7;13(1):8-17.
RGD ID: 724610
Pubmed: PMID:11145837   (View Abstract at PubMed)
DOI: DOI:10.1006/cyto.2000.0800   (Journal Full-text)

Peptidoglycan recognition protein (PGRP) binds to peptidoglycan (PG) or live bacteria and is upregulated by PG. PGRP is a ubiquitous protein involved in innate immunity. Tag7, a novel cytokine, is also induced by bacterial products; tag7 is apoptotic to murine L929 cells in a NF-kappaB-independent manner. Both of these genes are expressed in brain, lymphatic and haematopoietic tissues. We provide evidence that murine PGRP and tag7 encode identical transcripts and have structural relationships to lysozymes. Further, we have cloned the cDNA of rat PGRP and analyzed its expression in brains of sleep-deprived and control rats. The mRNA levels of PGRP/tag7 were measured by RT-PCR and compared to the housekeeping gene porphobilinogen deaminase (PBD). PGRP was constitutively expressed in rat brain. PGRP mRNA was increased by 43% and 17% in the brainstem and hypothalamus, respectively, in sleep-deprived rats compared to controls. The upregulation of PGRP expression by sleep deprivation suggests a role for PGRP in a homeostatic regulation of sleep.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
immune response  TAS 724610 RGD 
regulation of circadian sleep/wake cycle, sleep  IEP 724610 RGD 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
peptidoglycan immune receptor activity  TAS 724610 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pglyrp1  (peptidoglycan recognition protein 1)

Additional Information