RGD Reference Report - The cloning of a rat peptidoglycan recognition protein (PGRP) and its induction in brain by sleep deprivation. - Rat Genome Database

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The cloning of a rat peptidoglycan recognition protein (PGRP) and its induction in brain by sleep deprivation.

Authors: Rehman, A  Taishi, P  Fang, J  Majde, JA  Krueger, JM 
Citation: Rehman A, etal., Cytokine 2001 Jan 7;13(1):8-17.
RGD ID: 724610
Pubmed: PMID:11145837   (View Abstract at PubMed)
DOI: DOI:10.1006/cyto.2000.0800   (Journal Full-text)

Peptidoglycan recognition protein (PGRP) binds to peptidoglycan (PG) or live bacteria and is upregulated by PG. PGRP is a ubiquitous protein involved in innate immunity. Tag7, a novel cytokine, is also induced by bacterial products; tag7 is apoptotic to murine L929 cells in a NF-kappaB-independent manner. Both of these genes are expressed in brain, lymphatic and haematopoietic tissues. We provide evidence that murine PGRP and tag7 encode identical transcripts and have structural relationships to lysozymes. Further, we have cloned the cDNA of rat PGRP and analyzed its expression in brains of sleep-deprived and control rats. The mRNA levels of PGRP/tag7 were measured by RT-PCR and compared to the housekeeping gene porphobilinogen deaminase (PBD). PGRP was constitutively expressed in rat brain. PGRP mRNA was increased by 43% and 17% in the brainstem and hypothalamus, respectively, in sleep-deprived rats compared to controls. The upregulation of PGRP expression by sleep deprivation suggests a role for PGRP in a homeostatic regulation of sleep.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Pglyrp1Ratimmune response  TAS  RGD 
Pglyrp1Ratregulation of circadian sleep/wake cycle, sleep  IEP  RGD 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Pglyrp1Ratpeptidoglycan immune receptor activity  TAS  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pglyrp1  (peptidoglycan recognition protein 1)


Additional Information